Focusing-free impedimetric differentiation of red blood cells and leukemia cells: A system optimization

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dc.contributor.authorBilican, Ismail
dc.contributor.authorGuler, Mustafa Tahsin
dc.contributor.authorSerhatlioglu, Murat
dc.contributor.authorKirindi, Talip
dc.contributor.authorElbuken, Caglar
dc.date.accessioned2021-01-14T18:10:47Z
dc.date.available2021-01-14T18:10:47Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionGULER, MUSTAFA TAHSIN/0000-0002-0478-3183
dc.description.abstractA focusing-free microfluidic impedimetric cell detection system is developed. The effect of the channel dimensions, solution conductivity, excitation voltage, and particle size on impedimetric signal outputs were optimized to increase the sensitivity of the system. Conventional microfabrication techniques were adapted to obtain low height, resealable microchannels. The geometry optimization was performed by a combination of analytical, numerical and experimental approaches. The results demonstrate that reliable impedimetric particle differentiation can be achieved without any labeling or particle focusing. The system parameters were studied and rule-of-thumb design criteria were provided. Finally, using the developed system, red blood cells and leukemia cells were experimentally detected and differentiated. Thanks to its simplicity, the focusing-free cell differentiation system may find applications in several cellular diagnostic uses.en_US
dc.description.sponsorshipKirikkale University (BAP Project)Kirikkale University [2016/077]; TUBITAK Scientific Support Department within the scope of 2211-Domestic PhD scholarship programTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis study was financially supported by Kirikkale University (BAP Project No: 2016/077). Ismail Bilican was supported by TUBITAK Scientific Support Department within the scope of 2211-Domestic PhD scholarship program. The authors thank Ziya Isiksacan for proofreading the manuscript.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.snb.2019.127531
dc.identifier.issn0925-4005
dc.identifier.scopus2-s2.0-85077653198
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.snb.2019.127531
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12775
dc.identifier.volume307en_US
dc.identifier.wosWOS:000508110400028
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherELSEVIER SCIENCE SAen_US
dc.relation.ispartofSENSORS AND ACTUATORS B-CHEMICAL
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImpedance spectroscopyen_US
dc.subjectRed blood cellen_US
dc.subjectWhite blood cellen_US
dc.subjectLeukemiaen_US
dc.subjectMicrofluidic flow cytometryen_US
dc.titleFocusing-free impedimetric differentiation of red blood cells and leukemia cells: A system optimizationen_US
dc.typeArticle

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