The therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats

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dc.authoridSipahi, Mehmet/0000-0001-8344-9863
dc.contributor.authorAkarca-Dizakar, Saadet Özen
dc.contributor.authorDemirel, Mürşide Ayşe
dc.contributor.authorCoşkun Akçay, Neslihan
dc.contributor.authorSipahi, Mehmet
dc.contributor.authorKarakoç Sökmensüer, Lale
dc.contributor.authorBoyunaga, Hakan
dc.contributor.authorKöylü, Ayşe
dc.date.accessioned2025-01-21T16:55:22Z
dc.date.available2025-01-21T16:55:22Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study was to evaluate the effects of coenzyme Q10 in the treatment of endometriosis rat models. Twenty seven Sprague Dawley rats were divided into four groups; Control Group (n = 7; Endometriosis group), Reference Group (n = 6; Endometriosis + Buserelin acetate, 20 mg/kg), CoQ10 Group-I (n = 7; Endometriosis + CoQ10, 50 mg/kg) and CoQ10 Group-II (n = 7; Endometriosis + CoQ10, 100 mg/kg). At the end of the experiment, all the rats were sacrificed, and the volume and histoarchitecture of endometrial implants were evaluated. The mast cells were determined by Toluidine blue and collagen fiber density was analysed by Masson's Trichrome staining. Tumour necrosis factor and vascular endothelial growth factor (VEGF) levels were analysed by enzyme-linked immunosorbent assay in peritoneal fluid and VEGF and matrix metalloproteinase-9 (MMP-9) were evaluated by immunohistochemistry. Terminal deoxynucleotidil transferase-mediated dUTP Nick end labelling (TUNEL) was also used for the detection of apoptotic cells. The CoQ10 treatment significantly decreased the volume of endometriotic implants, VEGF, and MMP-9 immunoreactivity and increased TUNEL-positive cells. The findings of the study suggest that CoQ10 can be used in endometriosis treatment by suppressing the endometriotic implants.IMPACT STATEMENT What is already known on this subject? Endometriosis is a gynaecological disorder and previous studies have shown that different treatments with antioxidants cause significant regression in the endometriotic implants. What the results of this study add? In this study, CoQ10 reduced intra-abdominal adhesion scores and volume of the endometriotic implants. In addition, CoQ10 treatment affected mast cell, TNF-alpha, VEGF, and MMP-9. What of these findings for clinical practice and/or further research? CoQ10 treatments may be possible to apply, it can contribute to science in terms of a new therapeutic treatment for endometriosis. Further studies are required to evaluate the Coenzyme Q10's effects on pain and subfertility in endometriosis.
dc.description.sponsorshipProjects of Scientific Investigation at Gazi University [01/2019-17]
dc.description.sponsorshipThis study was supported by the Projects of Scientific Investigation at Gazi University [grant number 01/2019-17].
dc.identifier.doi10.1080/01443615.2022.2114322
dc.identifier.endpage3298
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7
dc.identifier.pmid36048875
dc.identifier.scopus2-s2.0-85137091388
dc.identifier.scopusqualityQ3
dc.identifier.startpage3290
dc.identifier.urihttps://doi.org/10.1080/01443615.2022.2114322
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25769
dc.identifier.volume42
dc.identifier.wosWOS:000849763500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCoenzyme Q10; endometriosis; infertility; VEGF; MMP-9
dc.titleThe therapeutic effects of coenzyme Q10 on surgically induced endometriosis in Sprague Dawley rats
dc.typeArticle

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