Protective Effect of Hypothermia in a Blunt Thoracic Trauma and Hemorrhagic Shock Model

Basit Öğe Kaydı
dc.contributor.authorÜlger, Hüseyin
dc.contributor.authorDeniz, Turgut
dc.contributor.authorÇomu, Faruk
dc.contributor.authorAğalar, Canan
dc.contributor.authorKısa, Üçler
dc.contributor.authorAğalar, Fatih
dc.date.accessioned2020-06-25T18:07:54Z
dc.date.available2020-06-25T18:07:54Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractBackground The aim of this study was to investigate the effect of volume-controlled hemorrhage and hypothermia on rats with blunt chest trauma, evaluating bacterial translocation (BT), lung tissue malondialdehyde (MDA), nitric oxide (NO) levels, and erythrocyte deformability (ED). Methods In our study, 10 animals each were included in 6 groups. Groups were as follows: a group with blunt chest trauma only (Group T), a group with hemorrhage only (Group H), a normothermic group with comorbidity of trauma and hemorrhage (Group NT), a mild hypothermic group with trauma and hemorrhage (Group MH), a moderate hypothermic group with trauma and hemorrhage (Group MoH), and a control group (Group C). Sodium pentobarbital (50 mg/kg, intraperitoneally) anesthesia was administered. Thoracic trauma was generated using kinetic energy at the middle of the chest (2.45 J). Stage 3 hemorrhagic shock was initiated. After 24 hours, the rats were killed and red blood cell deformability, BT development in the liver, spleen, and mesenteric lymph nodes, and NO and MDA levels in lung tissue, kept at -80 degrees C, were measured. Results In Groups MH and MoH, there was no difference in ED values, though they were lower than those in Group NT (p < 0.05). BT was more prevalent in Group NT than in the other groups. In Group NT, the growth of BT was greater than in other groups (p < 0.05). The level of NO in Group H was higher than in the control group (p < 0.05). In Group MoH, the level of MDA was lower than in Group MH (p < 0.05). Conclusion Hypothermia seems to demonstrate protective effects on ED and BT by reducing oxidative stress. The protective effects of therapeutic hypothermia on ED may be due to the effect of reducing NO and/or MDA. There was no difference in effect between mild and moderate hypothermia in terms of the formation of ED and BT.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-0034-1394103
dc.identifier.endpage721en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue8en_US
dc.identifier.pmid25361017
dc.identifier.scopus2-s2.0-84928574368
dc.identifier.scopusqualityQ2
dc.identifier.startpage716en_US
dc.identifier.urihttps://doi.org/10.1055/s-0034-1394103
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5689
dc.identifier.volume62en_US
dc.identifier.wosWOS:000346338600014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchesten_US
dc.subjecttraumaen_US
dc.subjectexperimentalen_US
dc.subjecthypothermia/circulatory arresten_US
dc.subjectinfectionen_US
dc.subjectshocken_US
dc.titleProtective Effect of Hypothermia in a Blunt Thoracic Trauma and Hemorrhagic Shock Modelen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Protective Effect of Hypothermia in a Blunt Thoracic Trauma and Hemorrhagic Shock Model.pdf
Boyut:
194.37 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Daha fazla yükle