Investigation of the biocompatibility and in vivo wound healing effect of Cotinus coggygria extracts

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dc.authoridEkici, Hüsamettin/0000-0001-6403-737X
dc.contributor.authorBozkaya, Esra
dc.contributor.authorTürk, Mustafa
dc.contributor.authorEkici, Hüsamettin
dc.contributor.authorKarahan, Siyami
dc.date.accessioned2025-01-21T16:33:56Z
dc.date.available2025-01-21T16:33:56Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractCotinus coggygria is widely recognized its antiseptic, anti-inflammatory, antimicrobial, antihemorrhagic, and wound-healing properties. In this, aimed to evaluate the phenolic contents, cytotoxicity/proliferation, hemolytic, antimicrobial, genotoxic, apoptotic, necrotic activities, and in vivo wound healing effects of C. coggygria, , a plant species known to have beneficial effects on wound healing. TOF-LC/MS analyzes revealed that the methanol extract of C. coggygria leaves contained flavonoids and phenolic compounds such as gallic acid (18.5 mg/kg), catechin (4.6 mg/kg), protocatesic acid (0.6 mg/kg), vanillic acid (8.4 mg/kg), ellagic acid (0.1 mg/kg), rosmarinic acid (0.1 mg/kg), quercetin (15 ppb) and C. coggygria stems contained such as gallic acid (24.6 mg/kg), catechin (155.1 mg/kg), chlorogenic acid (1.9 mg/kg), 4hydroxybenzoic acid (383.3 mg/kg), rutin (2.5 mg/kg), ellagic acid (15.1 mg/kg), apigenin 7-glycoside (10.5 mg/kg), rosmarinic acid (0,4 mg/kg), quercetin (15.2 mg/kg), naringenin (279.1 mg/kg). Consequently, C. coggyria has a positive effect on wound healing with antibacterial properties, particularly against E. coli, and without cytotoxic, genotoxic, or hemolytic effects at test concentrations. In the in vivo burn model, wounds treated with leaf and stem extracts healed faster than the control group. Thus, C. coggygria is an effective plant for wound healing with antibacterial properties, particularly against E. coli, and without cytotoxic, genotoxic, and hemolytic effects.
dc.description.sponsorshipMinistry of Science, Industry and Technology SANTEZ of the Ministry of Science, Industry and Technology [0352.STZ.2013-2]
dc.description.sponsorshipThis study was financially supported by the Ministry of Science, Industry and Technology SANTEZ Project No. 0352.STZ.2013-2 of the Ministry of Science, Industry and Technology.
dc.identifier.doi10.33988/auvfd.1217177
dc.identifier.endpage280
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85201280237
dc.identifier.scopusqualityQ3
dc.identifier.startpage269
dc.identifier.trdizinid1249210
dc.identifier.urihttps://doi.org/10.33988/auvfd.1217177
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1249210
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23884
dc.identifier.volume71
dc.identifier.wosWOS:001281868800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCytotoxicity; Cotinus coggygria; Genotoxicity; Hemolysis; In vivo wound healing
dc.titleInvestigation of the biocompatibility and in vivo wound healing effect of Cotinus coggygria extracts
dc.typeArticle

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