Protective Effects of Boron on Cyclophosphamide-Induced Bladder Damage and Oxidative Stress in Rats

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dc.contributor.authorAyhancı, Adnan
dc.contributor.authorTanriverdi, Döndü Tuğçe
dc.contributor.authorŞahintürk, Varol
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAppak-Baskoy, Sıla
dc.contributor.authorŞahin, İlknur Kulcanay
dc.date.accessioned2021-01-14T18:10:25Z
dc.date.available2021-01-14T18:10:25Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionSAHINTURK, VAROL/0000-0003-2317-3644; Appak-Baskoy, Sila/0000-0001-6105-1408
dc.description.abstractThis study aims to investigate protective effects of boron against cyclophosphamide-induced bladder toxicity that produces oxidative stress and leads to apoptosis of the cells. In total, 24 rats were divided into 4 equal groups. The control group received saline. The 2nd experimental group received 200 mg kg of cyclophosphamide i.p. on the 4th day while the 3rd group was given only boron (200 mg kg, i.p.) for 6 days. In the 4th group, boron was given for 6 days and cyclophosphamide (200 mg kg, i.p.) was administrated on the 4th day. Twenty-four hours after the last boron or cyclophosphamide administration, rats were sacrificed under anesthesia. Bladder tissues of rats were taken for histological and immunohistochemical (apoptotic markers such as caspase-3, bcl-2, and bax) and blood was taken for the biochemical (serum total thiol, serum natural thiol, serum thiol-disulfide) analysis. Transient epithelial thinning, edema, marked inflammatory reaction, and bleeding were observed in bladders of the group that received cyclophosphamide. Also, the activity of bax and caspase-3-positive cells increased while the number of bcl-2-positive cells decreased. In the same group, serum natural thiol and total thiol levels decreased while serum disulfide levels increased, which indicates oxidative stress. On the other hand, in the boron+cyclophosphamide group pretreatment with boron protected, the bladder tissue and the number of bcl-2-positive cells increased, and bax and caspase-3-positive cells decreased, showing antiapoptotic effects of boron against cyclophosphamide-induced toxicity. In parallel with the findings of this group, native thiol and total thiol levels increased and serum disulfide levels decreased pointing out to a decreased oxidative stress. Our results indicate that boron pretreatment significantly protects rat bladder against cyclophosphamide-induced bladder damage due to its antiapoptotic and antioxidant properties.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s12011-019-01969-z
dc.identifier.endpage191en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid31734911
dc.identifier.scopus2-s2.0-85080939425
dc.identifier.scopusqualityQ1
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-019-01969-z
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12588
dc.identifier.volume197en_US
dc.identifier.wosWOS:000547390800020
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCH
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectBladderen_US
dc.subjectBoronen_US
dc.subjectApoptosisen_US
dc.subjectOxidative stressen_US
dc.subjectThiolen_US
dc.titleProtective Effects of Boron on Cyclophosphamide-Induced Bladder Damage and Oxidative Stress in Ratsen_US
dc.typeArticle

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