Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients

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dc.contributor.authorYuce-Artun, Nazan
dc.contributor.authorBaskak, Bora
dc.contributor.authorOzel-Kizil, Erguvan Tugba
dc.contributor.authorOzdemir, Hatice
dc.contributor.authorUckun, Zuhal
dc.contributor.authorDevrimci-Ozguven, Halise
dc.contributor.authorSuzen, Halit Sinan
dc.date.accessioned2020-06-25T18:16:41Z
dc.date.available2020-06-25T18:16:41Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionozguven, halise/0000-0002-9355-2757; Suzen, Sinan/0000-0003-1779-5850; OZEL-KIZIL, ERGUVAN TUGBA/0000-0001-9657-1382
dc.description.abstractBackground Genetic polymorphisms in CYP2B6 and CYP2C19 may cause variability in the metabolism of sertraline, a widely used antidepressant in major depressive disorder treatment. Objective This study investigates the impact of CYP2B6*4 (785A > G), CYP2B6*9 (516G > T), CYP2B6*6 (516G > T + 685G > A) CYP2C19*2 (685G > A), CYP2C19*17 (-3402C > T) polymorphisms on plasma concentrations of sertraline and N-desmethyl sertraline in major depression patients treated with sertraline [n = 50]. Setting Participants were patients who admitted to an adult psychiatry outpatient unit at a university hospital. These were DSM-IV major depression diagnosed patients with a stable sertraline medication regimen [for at least one month]. Methods CYP2B6*4 (rs 2279343; 785A > G), CYP2B6*9 (516G > T; rs 3745274), CYP2B6*6 (516G > T + 685G > A) CYP2C19*2 (rs 4244285; 685G > A), CYP2C19*17 (rs 11188072; -3402C > T), polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism. Plasma concentrations were measured by high-performance liquid chromatography in patients treated with SERT. Main outcome measure The distribution of CYP2B6*4, *6, *9 and CYP2C19*2, *17 among patient group and the association between genotype and sertraline metabolism. Results Sertraline, N-desmethyl sertraline, N-desmethyl sertraline/sertraline and dose-adjusted plasma concentrations were statistically compared between individuals with wild-type and variant alleles both for CYP2B6 and CYP2C19 enzymes. The mean N-desmethyl sertraline/sertraline value, was significantly lower in all subgroups with *6 and *9 variant alleles (p < 0.05). Sertraline/C values were significantly higher (p < 0.05) and N-desmethyl sertraline/C values were lower in all subgroups with *6 and *9 variant alleles compared to wild-type subgroup. Conclusion CYP2B6*6 and *9 variant alleles had a significant decreasing effect on sertraline metabolism in major depression patients which might result as variations in sertraline therapy.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s11096-016-0259-8
dc.identifier.endpage394en_US
dc.identifier.issn2210-7703
dc.identifier.issn2210-7711
dc.identifier.issue2en_US
dc.identifier.pmid26830411
dc.identifier.scopus2-s2.0-84962958394
dc.identifier.scopusqualityQ1
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.1007/s11096-016-0259-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6596
dc.identifier.volume38en_US
dc.identifier.wosWOS:000374326900029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal Of Clinical Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCYP2B6en_US
dc.subjectCYP2C19en_US
dc.subjectCytochrome P450en_US
dc.subjectSertralineen_US
dc.subjectPharmacogeneticsen_US
dc.titleInfluence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patientsen_US
dc.typeArticle

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