The correlation of TNF alpha levels with acute phase proteins in acute Toxoplasma gondii infection in mice

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dc.authoridATMACA, HASAN TARIK/0000-0001-8379-4114
dc.contributor.authorAtmaca, Nurgul
dc.contributor.authorAtmaca, Hasan Tarik
dc.date.accessioned2025-01-21T16:44:56Z
dc.date.available2025-01-21T16:44:56Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAcute Toxoplasma gondii infections can influence the liver as well as other organs. Many cytokines and proteins play a role in the acute response against infection. Tumor necrosis factor alpha (TNF alpha) is a cytokine that plays a key function in stimulating hepatocytes to produce acute phase proteins. In this study, we investigated TNF alpha levels associated with the levels of macroglobulin, haptoglobin, hemopexin, C-reactive protein (CRP), albumin, serum amyloid alpha protein (SAA), and clusterin, which are acute phase proteins, in serum of mice with T. gondii infection. In the experiment, a total of 24 mice were used; 6 mice constituted the control group and 18 mice were infected with the RH strain. On the 2nd, 4th, and 6th days following the infection, 6 animals were euthanized, and their serums were collected. Compared to the control group, we observed a statistically significant decrease in albumin concentration in the group with T. gondii infection on the 6th day. Also, this group displayed a statistically significant, gradual increase in clusterin levels on the 2nd and 6th days, C-reactive protein levels on the 4th day, haptoglobin levels on the 2nd and 4th days, hemopexin levels on the 2nd day, serum amyloid A levels on the 2nd, 4th, and 6th days, and TNF-alpha levels on the 2nd, 4th, and 6th days (p < 0.05). TNF-alpha was strongly positively correlated with CRP, SAA, and clusterin, moderately positively correlated with hemopexin, and strongly negatively correlated with albumin. The increase in CRP, SAA, clusterin, and hemopexin levels on the 2nd day after infection, in parallel with the increase in TNF-alpha levels, indicates that these proteins can be considered as major acute phase proteins in acute T. gondii infection in mice. The data obtained here may be helpful for the diagnosis of T. gondii infection and for monitoring treatments.
dc.description.sponsorshipKirikkale Univer-sity, Scientific Research Council
dc.description.sponsorshipThis work was partially supported by grants from Kirikkale Univer-sity, Scientific Research Council. A professional editor edited the lan-guage some part of this manuscript (protranslate.net) .
dc.identifier.doi10.1016/j.exppara.2022.108311
dc.identifier.issn0014-4894
dc.identifier.issn1090-2449
dc.identifier.pmid35724932
dc.identifier.scopus2-s2.0-85132539027
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.exppara.2022.108311
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25556
dc.identifier.volume239
dc.identifier.wosWOS:000833544400010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofExperimental Parasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectToxoplasma gondii; Acute phase proteins; TNF alpha; Mice; Liver; Immunohistochemistry
dc.titleThe correlation of TNF alpha levels with acute phase proteins in acute Toxoplasma gondii infection in mice
dc.typeArticle

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