Comparison of side effects of oxytetracycline and talc pleurodesis: an experimental study

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dc.contributor.authorGözübüyük, Alper
dc.contributor.authorÖzpolat, Berkant
dc.contributor.authorÇiçek, Ali Fuat
dc.contributor.authorÇaylak, Hasan
dc.contributor.authorYücel, Orhan
dc.contributor.authorKavaklı, Kuthan
dc.contributor.authorGenç, Onur
dc.date.accessioned2020-06-25T17:49:02Z
dc.date.available2020-06-25T17:49:02Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzpolat, Berkant/0000-0002-6203-7306;
dc.description.abstractBackground: Chemical pleurodesis is widely recommended in the treatment of refractory pleural effusion or pulmonary air leak of different etiologies. Although several agents have been used, many questions have remained unanswered about their toxicity. Talc is the most commonly used agent for the treatment, with rare, serious complications reported. Oxytetracycline pleurodesis in clinical practice has been described in a few studies, but literature reveals no experimental studies using this agent. We performed a prospective, randomized, observer-blinded, controlled study to evaluate the changes in lung histology and systemic response to pleurodesis with oxytetracycline and talc in acute and subacute phases in a rat model. Methods: Forty-two male albino Wistar rats were divided into three groups and 3 subgroups with 7 animals in each. Group 1 was given oxytetracycline, 35 mg/kg; Group 2 was given talc slurry, 60 mg/kg in 0.5 mL saline solution, and Group 3 was given only 0.5 mL saline intrapleurally. In subgroups "a" the nimls were sacrificed at the postoperative 72(nd) hour and, in subgroups "b", on the postoperative day 7. The surfaces were graded by microscopic examination. Results: Oxytetracycline produced alveolar collapse, hemorrhage, edema, inflammation at the postoperative 72(nd) hour and hemorrhage on the postoperative day 7, while talc produced significant edema, inflammation, proliferation, fibrosis at the postoperative 72(nd) hour and hemorrhage, edema, inflammation, proliferation, and fibrosis on the postoperative day 7 (p < 0,0042). Talc produced significant edema compared to oxytetracycline on the postoperative day 7. On contralateral side, oxytetracycline and talc produced significant hemorrhage on the postoperative day 7 (p < 0.0042). Conclusions: Both agents were shown to produce pulmonary lesions. In acute phase, the pulmonary side effects of oxytetracycline were more pronounced, whereas the side effects of talc were prolonged to subacute phase. We propose that the occasional side effects in humans may be related to these changes as were observed in our rat model, and like talc, oxytetracycline must be used cautiously in patients with limited respiratory function.en_US
dc.identifier.citationGözübüyük, A., Özpolat, B., Çiçek, A.F. et al. Comparison of side effects of oxytetracycline and talc pleurodesis: an experimental study. J Cardiothorac Surg 5, 128 (2010). https://doi.org/10.1186/1749-8090-5-128en_US
dc.identifier.doi10.1186/1749-8090-5-128
dc.identifier.issn1749-8090
dc.identifier.pmid21144032
dc.identifier.scopus2-s2.0-78649958736
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/1749-8090-5-128
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4621
dc.identifier.volume5en_US
dc.identifier.wosWOS:000285614100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmcen_US
dc.relation.ispartofJournal Of Cardiothoracic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleComparison of side effects of oxytetracycline and talc pleurodesis: an experimental studyen_US
dc.typeArticle

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