Malignant myoepithelioma of cranial dura

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dc.contributor.authorErdoğan, Sibel
dc.contributor.authorRodriguez, Fausto J.
dc.contributor.authorScheithauer, Bernd W.
dc.contributor.authorAbell-Aleff, Patrice C.
dc.contributor.authorRabin, Michael
dc.date.accessioned2020-06-25T17:43:48Z
dc.date.available2020-06-25T17:43:48Z
dc.date.issued2007
dc.description.abstractMalignant tumors of myoepithelial origin have been increasingly recognized at a variety of sites. Herein, we describe an example of malignant myoepithelioma arising in intracranial dura. The patient is a 47-year-old woman who presented with intracranial hemorrhage and on magnetic resonance imaging was found to have an enhancing tumor. No extracranial primary tumor was identified. A gross total resection was performed. Histologically, it varied in pattern from diffuse to focally (< 10%) ductular and consisted of epitheloid to spindle cells showing marked mitotic activity. Prominent infiltration of the dura was noted. Immunohistochemical stains showed convincing expression of cytokeratins (AE1/AE3 and CAM 5.2), S-100 protein, smooth muscle actin, and glial fibrillary acidic protein. Electron microscopy performed on formalin-fixed, paraffin-embedded tissue demonstrated cohesive cells with focal intermediate filament content and surface basal lamina formation at stromal interfaces. Occasional desmosomes with tonofilaments surrounded intercellular lumina containing masses of filamentous material. This example of malignant myoepithelioma is the first convincing primary salivary gland type tumor to arise in an intracranial location outside the sellar region or ear. Intracranial dura should be added to various sites at which this morphologically heterogenous tumor may arise.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/PAS.0b013e31802c98ae
dc.identifier.endpage811en_US
dc.identifier.endpageclosedAccessen_US
dc.identifier.issn0147-5185
dc.identifier.issue5en_US
dc.identifier.pmid17460467
dc.identifier.scopus2-s2.0-34247609762
dc.identifier.scopusqualityQ1
dc.identifier.startpage807en_US
dc.identifier.urihttps://doi.org10.1097/PAS.0b013e31802c98ae
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3903
dc.identifier.volume31en_US
dc.identifier.wosWOS:000246135600021
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal Of Surgical Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmyoepitheliomaen_US
dc.subjectduraen_US
dc.subjectmeningeal tumoren_US
dc.subjectmalignant tumoren_US
dc.subjectirnmunohistochemistryen_US
dc.subjectelectron microscopyen_US
dc.titleMalignant myoepithelioma of cranial duraen_US
dc.typeArticle

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