Testicular nitric oxide and thiobarbituric acid reactive substances levels in obstructive azoospermia: A possible role in pathophysiology of infertility

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dc.contributor.authorBasar, M. Murad
dc.contributor.authorKısa, Üçler
dc.contributor.authorTuğlu, Devrim
dc.contributor.authorYılmaz, Erdal
dc.contributor.authorBasar, Halil
dc.contributor.authorCağlayan, Osman
dc.contributor.authorBatislam, Ertan
dc.date.accessioned2020-06-25T17:41:14Z
dc.date.available2020-06-25T17:41:14Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573; KISA, Ucler/0000-0002-8131-6810; Tuglu, Devrim/0000-0002-9777-3039
dc.description.abstractObjective. The aim of the study is to evaluate the levels of nitrite/nitrate and thiobarbituric acid reactive substances (TBARS) and their relationship with seminal parameters in experimental obstructive azoospermic rats to explain the possible mechanism of impaired sperm quality in obstructive azoospermia. Methods. A total of 10 male Spraque-Dawley rats underwent bilateral vas resection and ligation (Group-1 = vasectomy group). The findings were compared with control group (Group-2 = sham group, n = 10). Animals were sacrificed 8 weeks after surgery. Testes were removed and used for the evaluation of nitrate/nitrite and TBARS levels and for histology. Epididymal-aspirated seminal plasma was used for semen count and morphological analysis according to the Kruger criteria. Results. Testicular tissue nitrate/nitrite and TBARS levels were 35.7 +/- 3.1 mu mol/g protein and 3.7 +/- 0.1 nmol/g protein in Group-1, and 19.3 +/- 0.7 mu mol/g protein and 3.1 +/- 0.1 nmol/g protein in Group-2, respectively. Both parameters showed statistical differences between the two groups. Testicular tissue nitrate/nitrite and TBARS levels showed negative and statistically significant correlations with sperm motility and morphology. Conclusions. The present study showed that testicular nitrate/nitrite and TBARS levels were increased in obstructive azoospermia. For that reason, we concluded that antioxidant treatment can be recommended to patients before sperm extraction for artificial reproduction due to obstructive infertility after vasectomy reversal. Copyright (c) 2006 M. Murad Basar et al.en_US
dc.identifier.citationBaşar, M. M., Kisa, U., Tuğlu, D., Yilmaz, E., Başar, H., Cağlayan, O., & Batislam, E. (2006). Testicular nitric oxide and thiobarbituric acid reactive substances levels in obstructive azoospermia: a possible role in pathophysiology of infertility. Mediators of inflammation, 2006(3), 27458. https://doi.org/10.1155/MI/2006/27458en_US
dc.identifier.doi10.1155/MI/2006/27458
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.pmid16951488
dc.identifier.scopus2-s2.0-33645544365
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/MI/2006/27458
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3661
dc.identifier.volume2006en_US
dc.identifier.wosWOS:000240222800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltden_US
dc.relation.ispartofMediators Of Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleTesticular nitric oxide and thiobarbituric acid reactive substances levels in obstructive azoospermia: A possible role in pathophysiology of infertilityen_US
dc.typeArticle

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