Frequency of adiponectin gene polymorphisms in polycystic ovary syndrome and the association with serum adiponectin, androgen levels, insulin resistance and clinical parameters

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dc.contributor.authorDemirci, Hüseyin
dc.contributor.authorYilmaz, Murat
dc.contributor.authorErgun, Mehmet Ali
dc.contributor.authorYurtcu, Erkan
dc.contributor.authorBukan, Neslihan
dc.contributor.authorAyvaz, Göksun
dc.date.accessioned2020-06-25T17:51:14Z
dc.date.available2020-06-25T17:51:14Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionergun, mehmet ali/0000-0001-9696-0433
dc.description.abstractMaterials and methods. Ninety-six patients with PCOS and 93 healthy control subjects were included in the study. Insulin resistance was estimated via HOMA-IR. Serum adiponectin levels were measured by ELISA. For determination of adiponectin gene polymorphisms, PCR was performed with appropriate primers after genomic DNA was obtained from the peripheral blood of the patients and control subjects. Results. Adiponectin levels were low in patients with PCOS than control subjects. There was no significant statistical difference between the PCOS and control groups with respect to the frequency of polymorphisms and the genotype distribution. Adiponectin gene polymorphisms were not associated with the anthropometric parameters, hyperandrogenism and adiponectin levels in PCOS. However, the fasting insulin level and insulin resistance were significantly higher and more frequent, respectively, in the polymorphic group compared to the other genotypes among patients with PCOS. Conclusion. The risk of PCOS, hyperandrogenism in patients with PCOS and low serum adiponectin levels cannot be directly attributed to T45G adiponectin gene polymorphisms in exon 2, rather these polymorphisms may be associated with insulin resistance and hyperinsulinemia in PCOS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/09513590903367051
dc.identifier.endpage355en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue5en_US
dc.identifier.pmid20388053
dc.identifier.scopus2-s2.0-77951112854
dc.identifier.scopusqualityQ2
dc.identifier.startpage348en_US
dc.identifier.urihttps://doi.org/10.3109/09513590903367051
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4751
dc.identifier.volume26en_US
dc.identifier.wosWOS:000276624500008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectadiponectin gene polymorphismsen_US
dc.subjectinsulin resistanceen_US
dc.subjectandrogensen_US
dc.subjectadiponectinen_US
dc.titleFrequency of adiponectin gene polymorphisms in polycystic ovary syndrome and the association with serum adiponectin, androgen levels, insulin resistance and clinical parametersen_US
dc.typeArticle

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