Magnetic graphene oxide functionalized alginate-g-poly (2-hydroxypropylmethacrylamide) nanoplatform for near-infrared light/ pH/magnetic field-sensitive drug release and chemo/phototherapy
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Multifunctional nanoplatforms developed from natural polymers and graphene oxide (GO) with enhanced biological/physicochemical features have recently attracted attention in the biomedical field. Herein, a new multifunctional near -infrared (NIR) light-, pH- and magnetic field -sensitive hybrid nanoplatform (mGO@AL-gPHPM@ICG/EP) is developed by combining iron oxide decorated graphene oxide nanosheets (mGO) and poly(2hydroxypropylmethacrylamide) grafted alginate (AL-g-PHPM) copolymer loaded with indocyanine green (ICG) and etoposide (EP) for chemo/phototherapy. The functional groups, specific crystal structure, size, morphology, and thermal stability of the nanoplatform were fully characterized by XRD, UV, FTIR, AFM/TEM/FE-SEM, VSM, DSC/TG, and BET analyses. In this platform, the mGO and ICG, as phototherapeutic agents, demonstrate excellent thermal effects and singlet oxygen production under NIR-light (808 nm) irradiation. The XRD and DSC analysis confirmed the amorphous state of the ICG/EP in the nanoparticles. In vitro photothermal tests proved that the mGO@AL-g-PHPM@ICG/EP nanoparticles had outstanding light stability and photothermal conversion ability. The in vitro release profiles presented NIR light-, pH- and magnetic field -controlled EP/ICG release behaviors. In vitro experiments demonstrated the excellent antitumor activity of the mGO@AL-g-PHPM@ICG/EP against H1299 tumor cells under NIR laser. Benefiting from its low-cost, facile preparation, and good dualmodal therapy, the mGO@AL-g-PHPM@ICG/EP nanoplatform holds great promise in multi -stimuli -sensitive drug delivery and chemo/phototherapy.
Açıklama
Anahtar Kelimeler
Alginate copolymer; Multi -stimuli -sensitive nanoparticle; Magnetic graphene oxide; Etoposide; Indocyanine green; Phototherapy
Kaynak
International Journal of Pharmaceutics
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
659
