Magnetic graphene oxide functionalized alginate-g-poly (2-hydroxypropylmethacrylamide) nanoplatform for near-infrared light/ pH/magnetic field-sensitive drug release and chemo/phototherapy

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dc.contributor.authorGuncum, Enes
dc.contributor.authorGeyik, Gulcan
dc.contributor.authorIsiklan, Nuran
dc.date.accessioned2025-01-21T16:42:25Z
dc.date.available2025-01-21T16:42:25Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMultifunctional nanoplatforms developed from natural polymers and graphene oxide (GO) with enhanced biological/physicochemical features have recently attracted attention in the biomedical field. Herein, a new multifunctional near -infrared (NIR) light-, pH- and magnetic field -sensitive hybrid nanoplatform (mGO@AL-gPHPM@ICG/EP) is developed by combining iron oxide decorated graphene oxide nanosheets (mGO) and poly(2hydroxypropylmethacrylamide) grafted alginate (AL-g-PHPM) copolymer loaded with indocyanine green (ICG) and etoposide (EP) for chemo/phototherapy. The functional groups, specific crystal structure, size, morphology, and thermal stability of the nanoplatform were fully characterized by XRD, UV, FTIR, AFM/TEM/FE-SEM, VSM, DSC/TG, and BET analyses. In this platform, the mGO and ICG, as phototherapeutic agents, demonstrate excellent thermal effects and singlet oxygen production under NIR-light (808 nm) irradiation. The XRD and DSC analysis confirmed the amorphous state of the ICG/EP in the nanoparticles. In vitro photothermal tests proved that the mGO@AL-g-PHPM@ICG/EP nanoparticles had outstanding light stability and photothermal conversion ability. The in vitro release profiles presented NIR light-, pH- and magnetic field -controlled EP/ICG release behaviors. In vitro experiments demonstrated the excellent antitumor activity of the mGO@AL-g-PHPM@ICG/EP against H1299 tumor cells under NIR laser. Benefiting from its low-cost, facile preparation, and good dualmodal therapy, the mGO@AL-g-PHPM@ICG/EP nanoplatform holds great promise in multi -stimuli -sensitive drug delivery and chemo/phototherapy.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University [2021/066]
dc.description.sponsorshipThe authors would like to thank the Scientific Research Projects Coordination Unit of Kirikkale University [Project number: 2021/066, 2021] for their financial support. We extend our gratitude to Deva Holding A.S, (Turkey) for generously supplying the etoposide for this study. The authors would also like to thank Assist. Prof. Dr. Tuba OZDEMIR SANCI (AYBUMERLAB, Ankara Y & imath;ld & imath;r & imath;m Beyaz & imath;t University Central Research Laboratory Application and Research Center) for flow cytometry measurements and Prof. Dr. Siyami KARAHAN and Assist. Prof. Dr. Yasin O ZKABADAYI (KUBTUAM, K & imath;r & imath;kkale University Scientific and Technological Research Application and Research Center) for fluorescent microscope imaging.
dc.identifier.doi10.1016/j.ijpharm.2024.124287
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmid38815638
dc.identifier.scopus2-s2.0-85194917735
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2024.124287
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25072
dc.identifier.volume659
dc.identifier.wosWOS:001249755400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAlginate copolymer; Multi -stimuli -sensitive nanoparticle; Magnetic graphene oxide; Etoposide; Indocyanine green; Phototherapy
dc.titleMagnetic graphene oxide functionalized alginate-g-poly (2-hydroxypropylmethacrylamide) nanoplatform for near-infrared light/ pH/magnetic field-sensitive drug release and chemo/phototherapy
dc.typeArticle

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