Effect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamics

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dc.contributor.authorArıkan, Osman Kürşat
dc.contributor.authorAkarsu, Cengiz
dc.contributor.authorÜnal, Birsen
dc.contributor.authorErgin, Ahmet
dc.contributor.authorKoç, Can
dc.date.accessioned2020-06-25T17:41:05Z
dc.date.available2020-06-25T17:41:05Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: To determine the effect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamics in patients with open-angle glaucoma and to compare the results with those measured in healthy control participants. Study Design: Controlled, prospective clinical trial. Setting: University hospital. Methods: Thirty patients with open-angle glaucoma and 30 healthy volunteers as controls were topically self-administered oxymetazoline nasal spray three times a day (one spray in each nostril of 0.05% concentration) for 5 days continuously. Main Outcome Measures: Intraocular pressure and retrobulbar hemodynamics were measured in glaucomatous and normal eyes at baseline and at the end of oxymetazoline application. Results: Oxymetazoline nasal spray lowered intraocular pressure significantly in both the glaucoma group (p = .02) and the control group (p = .001) after 5 days of treatment. The systemic parameters in the glaucoma and control groups (systolic blood pressure, p = .14 and p = .17; diastolic blood pressure, p = .18 and p = .49; and pulse rate, p = .06 and p = .50, respectively) did not show statistically significant differences during the study period. Additionally, except with a significant decrease in the resistivity index of the central retinal artery in the glaucoma patients (p = .001), oxymetazoline nasal spray did not result in any significant changes in the retrobulbar hemodynamics in both the glaucoma and control groups. Conclusions: This study showed that a 5-day treatment with oxymetazoline nasal spray reduced intraocular pressure in both healthy controls and patients with glaucoma under treatment. In addition, it had no significant adverse effects on the retrobulbar hemodynamics.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.2310/7070.2005.4102
dc.identifier.endpage35en_US
dc.identifier.issn0381-6605
dc.identifier.issue1en_US
dc.identifier.pmid16527014
dc.identifier.scopus2-s2.0-33645023567
dc.identifier.scopusqualityN/A
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.2310/7070.2005.4102
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3627
dc.identifier.volume35en_US
dc.identifier.wosWOS:000236137100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherB C Decker Incen_US
dc.relation.ispartofJournal Of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcolour Doppler imagingen_US
dc.subjectglaucomaen_US
dc.subjectintraocular pressureen_US
dc.subjectoxymetazoline nasal sprayen_US
dc.subjectretrobulbar hemodynamicsen_US
dc.titleEffect of oxymetazoline nasal spray on intraocular pressure and retrobulbar hemodynamicsen_US
dc.typeArticle

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