Stem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bones

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dc.contributor.authorIsoglu, Ismail Alper
dc.contributor.authorBolgen, Nimet
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorVargel, Ibrahim
dc.contributor.authorCelik, Hakan Hamdi
dc.contributor.authorKilic, Emine
dc.contributor.authorPiskin, Erhan
dc.date.accessioned2020-06-25T18:34:35Z
dc.date.available2020-06-25T18:34:35Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionBolgen, Nimet/0000-0003-3162-0803; Meydanli, E. Elif Guzel/0000-0001-9072-3322; Cetinkaya, Duygu Uckan/0000-0003-3593-6493; KILIC, Emine/0000-0003-2984-7638; Weeks, Jason/0000-0001-5537-6927
dc.description.abstractRepair of cranial bone defects is an important problem in the clinical area. The use of scaffolds combined with stem cells has become a focus in the reconstruction of critical-sized bone defects. Electrospinning became a very attracting method in the preparation of tissue engineering scaffolds in the last decade, due to the unique nanofibrous structure of the electrospun matrices. However, they have a limitation for three dimensional (3D) applications, due to their two-dimensional structure and pore size which is smaller than a cellular diameter which cannot allow cell migration within the structure. In this study, electrospun poly(epsilon-caprolactone) (PCL) membranes were spirally wounded to prepare 3D matrices composed of nanofibers and macrochannels. Mesenchymal stromal/stem cells were injected inside the scaffolds after the constructs were implanted in the cranial bone defects in rats. New bone formation, vascularisation and intramembranous ossification of the critical size calvarial defect were accelerated by using mesenchymal stem cells combined 3D spiral-wounded electrospun matrices.en_US
dc.description.sponsorshipTurkish Academy of SciencesTurkish Academy of Sciencesen_US
dc.description.sponsorshipThis study was performed in the context of the EU-FP6-NoE Expertissues Project. Erhan Piskin is supported by Turkish Academy of Sciences as a Honorary Member. This study was a part of PhD thesis of smail Alper isoglu. The thesis was supervised by Erhan Piskin.en_US
dc.identifier.citationİsmail Alper İşoğlu, Nimet Bölgen, Petek Korkusuz, İbrahim Vargel, Hakan Hamdi Çelik, Emine Kılıç, Elif Güzel, Tarık Çavuşoğlu, Duygu Uçkan & Erhan Pişkin (2019) Stem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bones, Artificial Cells, Nanomedicine, and Biotechnology, 47:1,1094-1100.en_US
dc.identifier.doi10.1080/21691401.2019.1593850
dc.identifier.endpage1100en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue1en_US
dc.identifier.pmid30942631
dc.identifier.scopus2-s2.0-85064222566
dc.identifier.scopusqualityQ1
dc.identifier.startpage1094en_US
dc.identifier.urihttps://doi.org/10.1080/21691401.2019.1593850
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7964
dc.identifier.volume47en_US
dc.identifier.wosWOS:000463175200003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone regenerationen_US
dc.subjectcranial defectsen_US
dc.subjectmesenchymal stem cellsen_US
dc.subjectelectrospinningen_US
dc.subjectscaffolden_US
dc.titleStem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bonesen_US
dc.typeArticle

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