Experimental evaluation of the effects of zoledronic acid on regenerate bone formation and osteoporosis in mandibular distraction osteogenesis

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dc.contributor.authorPampu, A. Alper
dc.contributor.authorDolanmaz, Doğan
dc.contributor.authorTüz, Hakan H.
dc.contributor.authorKarabacakoğlu, Aydin
dc.date.accessioned2020-06-25T17:43:30Z
dc.date.available2020-06-25T17:43:30Z
dc.date.issued2006
dc.description.abstractPurpose: The aim of this study was to evaluate the effects of systemically administered zoledronic acid (ZA) on the bone mineral density (BMD) and bone mineral content (BMC) at mandibular distraction sites in rabbits. Materials and Methods: Eighteen New Zealand white rabbits were randomly divided into 2 groups. Bone lengthening was performed in the left portion of the mandible through distraction osteogenesis at a rate of 0.5 mm every 12 hours for 5 days. While the experimental group rabbits were administered intravenous 0.1 mg/kg ZA, control group rabbits were given only saline infusion during operation. All animals were sacrificed at the end of the consolidation period of 28 days. The mandibles of all animals were removed and both the anterior and posterior pin regions of the regenerate and regenerate region were evaluated by dual energy x-ray absorptiometry (DEXA). BMD and BMC data were statistically analyzed. Results: Except for 1 rabbit from the experimental group that had an infection at the external pin region, all animals showed complete clinical healing. When the values in the group receiving ZA were compared with those of the control group, it was observed that the BMD values of the anterior pin region of regenerate, regenerate region, and posterior pin region increased by 23%, 20%, and 31%, respectively; and BMC values increased by 22%, 24%, and 32%, respectively. When data of these regions were compared, both BMD and BMC were found statistically different in all regions (P <.05). Conclusion: Results of this study showed that ZA had positive effects on new bone formation at and around the distraction gaps of the lengthened rabbit mandibles by distraction osteogenesis. (C) 2006 American Association of Oral and Maxillofacial Surgeons.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.joms.2006.04.038
dc.identifier.endpage1236en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue8en_US
dc.identifier.pmid16860215
dc.identifier.scopus2-s2.0-33745905914
dc.identifier.scopusqualityQ1
dc.identifier.startpage1232en_US
dc.identifier.urihttps://doi.org10.1016/j.joms.2006.04.038
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3741
dc.identifier.volume64en_US
dc.identifier.wosWOS:000239549400010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Oral And Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleExperimental evaluation of the effects of zoledronic acid on regenerate bone formation and osteoporosis in mandibular distraction osteogenesisen_US
dc.typeArticle

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