QT interval and dispersion differences between normal and prehypertensive patients: effects of autonomic and left ventricular functional and structural changes

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dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorGueneri, Mahmut
dc.contributor.authorTireli, Emine
dc.contributor.authorSahin, Oemer
dc.contributor.authorCelik, Turgay
dc.contributor.authorIyisoy, Atila
dc.date.accessioned2020-06-25T17:48:39Z
dc.date.available2020-06-25T17:48:39Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionCelik, Turgay/0000-0001-8418-0130
dc.description.abstractObjective: We aimed to investigate the effects of autonomic and left ventricular functional and structural changes on QT interval and dispersion differences between normal and prehypertensive patients. Methods: A total of 291 normotensive patients (<140/90 mmHg) (135 males, age range: 16-75 years, mean age: 45 11 years; 156 females, age range: 17-71 years, mean age 38 10 years) were enrolled into this cross-sectional case-controlled study. Patients were categorized into two groups according to their blood pressure (BP) levels as Group 1 - patients with normal BP (<120/80 mmHg) or Group 2 - patients with prehypertensive BP (120-139/80-89 mmHg). We evaluated autonomic states by using heart rate variability measurements. Left ventricular structure and functions were evaluated by using Doppler echocardiography in both normal and prehypertensive BP groups regarding their effect on QT intervals and QT dispersion. Statistical analyses (Student's t and Mann-Whitney U tests) were used to evaluate the differences in QT intervals and QT dispersion between the BP groups. Results: There were statistically significant differences between the two BP groups with respect to QT intervals and QT dispersion (for QT min, p<0.001, QTc min, p<0.001 and QT dispersion, p<0.001). We also detected that prehypertensive patients had increased sympathetic activity and slightly impaired left ventricular systolic and diastolic function (for low frequency power / high frequency power ratio -p=0.029, left ventricular ejection fraction - p=0.054, and transmitral peak A wave velocity - p<0.001). Conclusion: QT interval and dispersion differences are present in prehypertension. Moreover, these differences are independent of left ventricular mass. Autonomic changes can be effective on these differences between the patient groups. (Anadolu Kardiyol Derg 2009; 9: 15-22)en_US
dc.identifier.citationDoğru, M. T., Güneri, M., Tireli, E., Şahin, Ö., Çelik, T., İyisoy, A. (2009). QT interval and dispersion differences between normal and prehypertensive patients: effects of autonomic and left ventricular functional and structural changes. Anadolu Kardiyoloji Dergisi, 9(1), 15 - 22.en_US
dc.identifier.endpage22en_US
dc.identifier.issn1302-8723
dc.identifier.issue1en_US
dc.identifier.pmid19196568
dc.identifier.scopus2-s2.0-65549130571
dc.identifier.scopusqualityN/A
dc.identifier.startpage15en_US
dc.identifier.trdizinid88736
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4517
dc.identifier.volume9en_US
dc.identifier.wosWOS:000263427100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves Yayinciliken_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisi-The Anatolian Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertensionen_US
dc.subjectelectrocardiographyen_US
dc.subjectechocardiographyen_US
dc.subjectventricular functionen_US
dc.subjectautonomic nervous systemen_US
dc.subjectrepolarizationen_US
dc.titleQT interval and dispersion differences between normal and prehypertensive patients: effects of autonomic and left ventricular functional and structural changesen_US
dc.typeArticle

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