Cognitive control of a simple mental image in patients with obsessive-compulsive disorder

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dc.contributor.authorKocak, Orhan Murat
dc.contributor.authorOzpolat, Aysegul Yilmaz
dc.contributor.authorAtbasoglu, Cem
dc.contributor.authorCicek, Metehan
dc.date.accessioned2020-06-25T17:51:44Z
dc.date.available2020-06-25T17:51:44Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionCicek, Metehan/0000-0002-8782-2191; Atbasoglu, E. Cem/0000-0002-8211-6095
dc.description.abstractThe nature of obsessions has led researchers to try to determine if the main problem in obsessive-compulsive disorder (OCD) is impaired inhibitory control. Previous studies report that the effort to suppress is one of the factors that increase the frequency of obsessive thoughts. Based on these results and those of the present study that suggest inferior parietal lobe (IPL) abnormality in OCD and findings of a recent study that reported the importance of the right posterior parietal cortex in cognitive control of a simple mental image, the present cognitive control paradigm study aimed to determine whether there is a difference in brain dynamics between OCD patients and non-obsessive controls while performing tasks that necessitate cognitive control of a simple mental image, and whether the right posterior parietal region is one of the regions in which a difference in activity between the OCD patients and controls would be observed. Functional brain imaging was performed while the participants attempted to suppress, imagine, or manipulate a mental image. The general linear model showed that there was a main effect of group and main effect of task. Accordingly, in all contrasts (suppression minus free-imagination, erasing minus free-imagination, and imagination minus free-imagination), the right IPL, right posterior cingulate cortex, and right superior frontal gyrus activity were lower in the OCD patients than in the healthy controls. These results and the observed correlations between activity levels, and symptom and subjective performance scores are discussed. In conclusion, the results of the present study and those of previous studies suggest that the main problem in OCD might be difficulty activating the right frontoparietal networks during tasks that require cognitive control, which might result in the intrusiveness of obsessive thoughts. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipPsychiatric Association of Turkeyen_US
dc.description.sponsorshipThis study was supported by the Psychiatric Association of Turkey (2006). The authors thank the entire staff of Integra Imaging Center, where the data were collected.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.bandc.2011.03.020
dc.identifier.endpage399en_US
dc.identifier.issn0278-2626
dc.identifier.issn1090-2147
dc.identifier.issue3en_US
dc.identifier.pmid21507542
dc.identifier.scopus2-s2.0-79957930761
dc.identifier.scopusqualityQ1
dc.identifier.startpage390en_US
dc.identifier.urihttps://doi.org/10.1016/j.bandc.2011.03.020
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4972
dc.identifier.volume76en_US
dc.identifier.wosWOS:000291903700007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofBrain And Cognition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObsessive-compulsive disorderen_US
dc.subjectCognitive controlen_US
dc.subjectInferior parietal lobeen_US
dc.subjectInsular cortexen_US
dc.subjectSuperior frontal gyrusen_US
dc.subjectPosterior cingulate cortexen_US
dc.subjectFunctional magnetic resonance imaging (fMRI)en_US
dc.titleCognitive control of a simple mental image in patients with obsessive-compulsive disorderen_US
dc.typeArticle

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