Mild Hypothermia Improves Survival During Hemorrhagic Shock Without Affecting Bacterial Translocation

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dc.contributor.authorDeniz, Turgut
dc.contributor.authorAgalar, Canan
dc.contributor.authorÖzdoğan, Mehmet
dc.contributor.authorEdremitlioglu, Mustafa
dc.contributor.authorEryılmaz, Mehmet
dc.contributor.authorDevay, Seda Duygulu
dc.contributor.authorAğalar, Fatih
dc.date.accessioned2020-06-25T17:48:54Z
dc.date.available2020-06-25T17:48:54Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Accidental hypothermia in patients with hemorrhagic shock (HS) is associated with increased mortality. However, experimental mild and moderate hypothermia has beneficial effects. The mechanisms for beneficial effects of hypothermia have not been completely understood. Therefore, the aim of this study was to investigate the effect of hypothermia on survival, bacterial translocation (BT), and remote pulmonary injury in a controlled HS model in rats. Methods: HS was achieved by blood withdrawal through femoral vein. Rats in the normothermia group (group I) were maintained at 37C. Mild hypothermia group (group II) was observed at 32C that was spontaneously induced by exposure to ambient temperature. Moderate hypothermia of 28C was actively induced by external cooling in group III for 90 min. Survival and neurological deficit scores (NDS) were recorded at 24th hr. Mesenteric lymph nodes, liver and spleen samples were collected. Myeloperoxidase (MPO) and malondialdehyde (MDA) levels were measured in lung tissue. Results: Blood pressure significantly increased in hypothermia groups. Mild hypothermia significantly increased survival. No difference was found in BT rates in groups. Hypothermia was found to significantly decrease the NDS points in group III, compared to group I. There was no difference in lung tissue MPO levels among groups. Lung tissue MDA levels increased significantly in groups II and III. Conclusions: Mild hypothermia improved blood pressure, survival, and neurological outcome with a possible detrimental effect on pulmonary ROS production during HS in rats. These effects of hypothermia are not associated with BT.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/08941930802566706
dc.identifier.endpage28en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue1en_US
dc.identifier.pmid19191154
dc.identifier.scopus2-s2.0-59749102081
dc.identifier.scopusqualityQ1
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.1080/08941930802566706
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4587
dc.identifier.volume22en_US
dc.identifier.wosWOS:000263091700005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypothermiaen_US
dc.subjectShocken_US
dc.subjectBacterial translocationen_US
dc.subjectNeurological deficiten_US
dc.subjectPulmonary injuryen_US
dc.subjectControlled hemorrhagic shocken_US
dc.titleMild Hypothermia Improves Survival During Hemorrhagic Shock Without Affecting Bacterial Translocationen_US
dc.typeArticle

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