The post-operative analgesic effects of epidurally administered morphine and transdermal fentanyl patch after ovariohysterectomy in dogs

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dc.contributor.authorPekcan, Zeynep
dc.contributor.authorKoç, Bahattin
dc.date.accessioned2020-06-25T17:49:08Z
dc.date.available2020-06-25T17:49:08Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective To investigate the analgesic and side effects of epidural morphine or a fentanyl patch after ovariohysterectomy in dogs. Study design Prospective, randomized clinical study. Animals Twenty female mongrel dogs undergoing ovariohysterectomy. Methods The dogs were allocated to one of two groups: epidural morphine or transdermal fentanyl patch. Anaesthesia was induced with propofol and maintained with isoflurane. Morphine (0.1 mg kg-1) was administered epidurally in the epidural morphine group and a transdermal fentanyl patch was applied 24 hours before the operation in the fentanyl patch group. The heart rate, respiratory rate, body temperature, plasma cortisol concentration, and sedation and analgesia scores were recorded during the 24 hour post-operative period. Adverse effects such as vomiting, anorexia, skin reactions, urinary retention, and time to start licking the surgical site were also recorded. p < 0.05 was considered significant. Statistical analyses utilized anova for repeated measures, Friedman tests, Mann-Whitney U-tests and independent sample t-tests as relevant. Results Pain scores were lower in the epidural group than in the fentanyl group at all post-operative times. The dogs in the epidural morphine group were calm and relaxed, whereas discomfort and vocalization were recorded in the fentanyl patch group. The sedation scores were higher in the fentanyl patch group throughout the 12 hour period. Salivation and anorexia lasted longer in the fentanyl patch group than in the epidural morphine group. Plasma cortisol concentrations were high in the early post-operative period in both groups. The fentanyl patch group had higher cortisol concentrations than the epidural morphine group. Slight erythema was recorded in two dogs when the patches were removed. Conclusion and clinical relevance Epidurally administered morphine provided better analgesia and caused fewer adverse effects than the fentanyl patch after ovariohysterectomy in dogs.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1467-2995.2010.00571.x
dc.identifier.endpage565en_US
dc.identifier.issn1467-2987
dc.identifier.issue6en_US
dc.identifier.pmid21040380
dc.identifier.scopus2-s2.0-78651491178
dc.identifier.scopusqualityQ1
dc.identifier.startpage557en_US
dc.identifier.urihttps://doi.org/10.1111/j.1467-2995.2010.00571.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4645
dc.identifier.volume37en_US
dc.identifier.wosWOS:000282816900010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofVeterinary Anaesthesia And Analgesia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanalgesiaen_US
dc.subjectdogen_US
dc.subjectepidural morphineen_US
dc.subjectextradural morphineen_US
dc.subjectfentanyl patchen_US
dc.titleThe post-operative analgesic effects of epidurally administered morphine and transdermal fentanyl patch after ovariohysterectomy in dogsen_US
dc.typeArticle

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