The Proportion of Tumour-Stroma in Metastatic Lymph Nodes is An Accurately Prognostic Indicator of Poor Survival for Advanced-Stage Colon Cancers

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dc.contributor.authorZengin, Mehmet
dc.contributor.authorBenek, Suat
dc.date.accessioned2021-01-14T18:10:29Z
dc.date.available2021-01-14T18:10:29Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionBenek, Suat/0000-0003-0774-7695
dc.description.abstractThe importance of tumour microenvironment in tumour behaviour has now become clearer. This study aimed to determine the prognostic effect of the proportion of tumour-stroma (PTS) in metastatic lymph nodes of advanced-stage colon cancers (CCs). We investigated PTS in positive lymph nodes of stage III-IV CC patients who underwent surgical treatment between 2004 and 2014. We used a standard approach in methodology. PTS was significantly associated with prognostic factors in the metastatic lymph nodes (perineural invasion [p = 0.031], lymphatic invasion [p = 0.032], invasive margin [p = 0.043], advanced pT [p = 0.020], and margin involvement [p = 0.034]). In addition, the correlations between PTS estimates (R = 0.704 to 0.617,p < 0.001), the reproducibility of the research (Kappa appa = 0.72-0.68) and the usefulness of the cut-off value (ROC: 50.33%; AUC = 0.752 [0.667-0.857]) were successful. In univariate analysis, 5-year survival was poor for RFS (p < 0.001), OS (p = 0.001) and LR (p = 0.013) in high PTS patients. Multivariate analysis confirmed that high PTS was an independent worse parameter for RFS (HR = 1.32, 95% CI: 1.17-2.55,p = 0.001) and OS (HR = 1.37, 95% CI: 1.25-1 - 2.56,p = 0.009). In this study, we showed that high PTS in metastatic lymph nodes was a successful prognostic marker for advanced-stage CCs. Also, the standard approach we used for the methodology was successful.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale UniversityKirikkale University [2020/052]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Kirikkale University. Project number: 2020/052.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1007/s12253-020-00877-1
dc.identifier.endpage2764en_US
dc.identifier.issn1219-4956
dc.identifier.issn1532-2807
dc.identifier.issue4en_US
dc.identifier.pmid32696416
dc.identifier.scopus2-s2.0-85088397041
dc.identifier.scopusqualityQ1
dc.identifier.startpage2755en_US
dc.identifier.urihttps://doi.org/10.1007/s12253-020-00877-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12632
dc.identifier.volume26en_US
dc.identifier.wosWOS:000551024800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSPRINGERen_US
dc.relation.ispartofPATHOLOGY & ONCOLOGY RESEARCH
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon cancersen_US
dc.subjectProportion of tumour-stromaen_US
dc.subjectPathologyen_US
dc.subjectPrognostic markersen_US
dc.subjectStage III-IVen_US
dc.titleThe Proportion of Tumour-Stroma in Metastatic Lymph Nodes is An Accurately Prognostic Indicator of Poor Survival for Advanced-Stage Colon Cancersen_US
dc.typeArticle

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