Isolated itching of external auditory canal: clinicopathological study with immunohistochemical determination of antimicrobial peptides

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dc.contributor.authorAcar, B.
dc.contributor.authorSimsek, G. Guler
dc.contributor.authorOguztuzun, S.
dc.contributor.authorZaim, M.
dc.contributor.authorKarasen, R. Murat
dc.date.accessioned2020-06-25T17:51:58Z
dc.date.available2020-06-25T17:51:58Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal. Materials and methods: A prospective, case-control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human beta-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared. Results: There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p < 0.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls (p > 0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human beta-defensin-3 or LL-37 cathelicidin. Conclusion: Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1017/S0022215110002161
dc.identifier.endpage230en_US
dc.identifier.issn0022-2151
dc.identifier.issue3en_US
dc.identifier.pmid21029502
dc.identifier.scopus2-s2.0-79957440790
dc.identifier.scopusqualityQ2
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.1017/S0022215110002161
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5042
dc.identifier.volume125en_US
dc.identifier.wosWOS:000287938000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal Of Laryngology And Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExternal Auditory Canalen_US
dc.subjectOtitis Externaen_US
dc.subjectPruritusen_US
dc.titleIsolated itching of external auditory canal: clinicopathological study with immunohistochemical determination of antimicrobial peptidesen_US
dc.typeArticle

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