The role of macrophages in the pathogenesis of mycosis fungoides

Basit Öğe Kaydı
dc.contributor.authorKara, D. O.
dc.contributor.authorOzsarac, K. C.
dc.contributor.authorUzar, M. K.
dc.contributor.authorBozdogan, O.
dc.contributor.authorGunduz, O.
dc.date.accessioned2020-06-25T18:22:54Z
dc.date.available2020-06-25T18:22:54Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionGunduz, Ozgur/0000-0003-1021-5219
dc.description.abstractBackgroundMacrophages are classified into classically activated (M1) and alternatively activated (M2) macrophages. Decrease in macrophage number in tumour tissue with treatment has been reported. AimThe aim of this study was to determine whether treatment has an effect on the number of dermal M1 and M2 macrophages in patients with mycosis fungoides (MF). MethodsIn total, 21 patients (8 women, 13 men; age range 42-73 years) were included in this study. We determined markers for dermal M1 (inducible nitric oxide synthase and CD68) and M2 (markers: CD163 and CD206) macrophages using double immunohistochemistry to reduce the error rate, and then counted the cells. ResultsThe number of dermal M1 cells was significantly lower pretreatment compared with post-treatment (P < 0.01). The numbers of dermal M2 cells were also numerically decreased by treatment. These results did not change significantly after exclusion of the patients who had recurrence (n = 2). There were no statistically significant differences between groups classified by stage, lesion type or treatment outcome. ConclusionMacrophage numbers are decreased in MF after treatment of tumour tissue.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/ced.13090
dc.identifier.endpage502en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue5en_US
dc.identifier.pmid28436576
dc.identifier.scopus2-s2.0-85020498213
dc.identifier.scopusqualityQ2
dc.identifier.startpage496en_US
dc.identifier.urihttps://doi.org/10.1111/ced.13090
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6948
dc.identifier.volume42en_US
dc.identifier.wosWOS:000403847100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofClinical And Experimental Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe role of macrophages in the pathogenesis of mycosis fungoidesen_US
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu