Decision making for promising quinoline-based anticancer agents through combined methodology

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dc.contributor.authorOzcan, Evrencan
dc.contributor.authorOkten, Salih
dc.contributor.authorEren, Tamer
dc.date.accessioned2021-01-14T18:10:37Z
dc.date.available2021-01-14T18:10:37Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionOkten, Salih/0000-0001-9656-1803; OZCAN, Evrencan/0000-0002-3662-6190
dc.description.abstractDuring the development of effective drugs for the treatment of cancer, one of the most important tasks is to identify effective drug candidates having maximum antiproliferation and minimum side effects. This paper considers the problem of selecting the most promising anticancer agents, showing inhibition at low IC50 concentration and low releasing lactate dehydrogenase percentage (cytotoxicity). Recently, we prepared quinoline analogs bearing different functional groups and determined their anticancer potential against the HeLa, C6, and HT29 cancer cell lines using different anticancer assays. Experimentally, seven quinoline derivatives consisting of different substituents were determined as promising anticancer agents. We propose a multicriteria recommendation method to identify the most promising anticancer agents against all tested cell lines with an accurate prediction algorithm according to the available input data. A multicriteria decision-making methodology (MCDM) was used for the solution of the relevant problem in this study. Both the experimental results and MCDM method indicated that 5,7-dibromo-8-hydroxyquinoline (2) and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (6) are the most promising anticancer agents against the HeLa, HT29, and C6 cell lines.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1002/jbt.22522
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue9en_US
dc.identifier.pmid32407595
dc.identifier.scopus2-s2.0-85084594143
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22522
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12701
dc.identifier.volume34en_US
dc.identifier.wosWOS:000532595000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanticancer effecten_US
dc.subjectIC50en_US
dc.subjectLDHen_US
dc.subjectmulticriteria decision makingen_US
dc.subjectquinolineen_US
dc.titleDecision making for promising quinoline-based anticancer agents through combined methodologyen_US
dc.typeArticle

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