Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma
Yükleniyor...
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pediatric cholesteatoma can be classified as congenital or acquired based on clinical criteria. We studied the expression patterns of five distinctive cytokeratins in both types of cholesteatoma in order to improve understanding of their pathogenesis and origin. A comparable expression pattern for CK10, CK14, CK18, CK19 and 34 beta E12 antigens was found in the matrix of congenital and acquired pediatric cholesteatoma. Our results demonstrate that congenital and acquired pediatric cholesteatoma exhibit an identical cytokeratin distribution pattern, suggesting that they share a common origin. Therefore, it seems possible that a portion of the so-called "acquired" cholesteatoma may actually originate from advanced congenital cholesteatoma with secondary destruction of the tympanic membrane in the pediatric patient population.
Açıklama
Olszewska, Ewa/0000-0002-9993-9266
Anahtar Kelimeler
cholesteatoma, cytokeratins, middle ear, epidermis
Kaynak
European Archives Of Oto-Rhino-Laryngology
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
262
Sayı
9
Künye
closedAccess
