Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma

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dc.contributor.authorOlszewska, E.
dc.contributor.authorLautermann, J.
dc.contributor.authorKoç, Can
dc.contributor.authorSchwaab, M.
dc.contributor.authorDazert, S.
dc.contributor.authorHildmann, H.
dc.contributor.authorSudhoff, H.
dc.date.accessioned2020-06-25T17:40:25Z
dc.date.available2020-06-25T17:40:25Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionOlszewska, Ewa/0000-0002-9993-9266
dc.description.abstractPediatric cholesteatoma can be classified as congenital or acquired based on clinical criteria. We studied the expression patterns of five distinctive cytokeratins in both types of cholesteatoma in order to improve understanding of their pathogenesis and origin. A comparable expression pattern for CK10, CK14, CK18, CK19 and 34 beta E12 antigens was found in the matrix of congenital and acquired pediatric cholesteatoma. Our results demonstrate that congenital and acquired pediatric cholesteatoma exhibit an identical cytokeratin distribution pattern, suggesting that they share a common origin. Therefore, it seems possible that a portion of the so-called "acquired" cholesteatoma may actually originate from advanced congenital cholesteatoma with secondary destruction of the tympanic membrane in the pediatric patient population.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00405-004-0875-0
dc.identifier.endpage736en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue9en_US
dc.identifier.pmid15754169
dc.identifier.scopus2-s2.0-26444613815
dc.identifier.scopusqualityQ1
dc.identifier.startpage731en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-004-0875-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3432
dc.identifier.volume262en_US
dc.identifier.wosWOS:000232405600007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcholesteatomaen_US
dc.subjectcytokeratinsen_US
dc.subjectmiddle earen_US
dc.subjectepidermisen_US
dc.titleCytokeratin expression pattern in congenital and acquired pediatric cholesteatomaen_US
dc.typeArticle

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