Progranulin and tumor necrosis factor-alpha in lean polycystic ovary syndrome patients

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dc.contributor.authorUzdogan, Andac
dc.contributor.authorPekcan, Meryem Kuru
dc.contributor.authorCil, Aylin Pelin
dc.contributor.authorKisa, Ucler
dc.contributor.authorAkbiyik, Filiz
dc.date.accessioned2025-01-21T16:43:47Z
dc.date.available2025-01-21T16:43:47Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective In this study, levels of progranulin (PGRN) and tumor necrosis factor-alpha (TNF-alpha) were measured to detect the presence of inflammation in lean polycystic ovary (PCOS) patients. Methods 40 lean PCOS patients were assessed by Rotterdam criteria. Forty healthy women with regular menstrual cycles and without biochemical and clinical hyperandrogenism were involved in our study. Blood samples were taken from the patient and control groups for the measurement of progranulin (PGRN), tumor necrosis factor-alpha (TNF-alpha), lipid parameters, glucose, insulin, and other hormones. Results Serum PGRN and TNF-alpha levels were significantly higher in patients with lean PCOS, compared with the control group (p = .037, p = .041). PGRN levels were positively correlated with TNF-alpha levels in lean PCOS patients. Conclusion PGRN is known as a ligand for the TNF-alpha receptor. PGRN level increase in lean PCOS patients may be due to inhibiting the inflammatory effects of TNF-alpha. To observe the PGRN and TNF-alpha connection in obesity, further study is needed in obese PCOS patients and obese control groups.
dc.identifier.doi10.1080/09513590.2021.1958311
dc.identifier.endpage929
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue10
dc.identifier.pmid34338562
dc.identifier.scopus2-s2.0-85111918654
dc.identifier.scopusqualityQ2
dc.identifier.startpage925
dc.identifier.urihttps://doi.org/10.1080/09513590.2021.1958311
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25326
dc.identifier.volume37
dc.identifier.wosWOS:000680267300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectPolycystic ovary syndrome; progranulin; tumor necrosis factor-alpha; inflammation
dc.titleProgranulin and tumor necrosis factor-alpha in lean polycystic ovary syndrome patients
dc.typeArticle

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