Preparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing material
Yükleniyor...
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study is preparation and characterization of alginate/chitosan sponges including a model antibiotic (i.e., ciprofloxacin) to use in wound and/or burn treatment. Sponges were prepared firstly by the gelation of sodium alginate followed by lyophilization, crosslinking with calcium chloride, and finally coating with chitosan. Sponges were characterized with respect to morphology, water uptake, in vitro drug release behavior, and antimicrobial activity. Investigated and evaluated parameters in all of these studies were selected as the concentration of calcium chloride, alginate viscosity, drug content, and molecular weight of chitosan. Drug release and water uptake were found to be greatly influenced by these parameters. Water uptake and drug release rate were decreased by increasing the crosslinking density, chitosan molecular weight, and alginate viscosity. In the antimicrobial tests, it was obtained that the antimicrobial activity is directly proportional with the release rates and water uptake. Morphological studies showed a highly porous structure with interconnected pores. (c) 2006 Wiley Periodicals, Inc.
Açıklama
Kececi, Kaan/0000-0003-1554-9058; GUVEN, EYLEM/0000-0001-9039-1698
Anahtar Kelimeler
alginate sponge, chitosan, wound dressing, ciprofloxacin release, antimicrobial activity
Kaynak
Journal Of Applied Polymer Science
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
101
Sayı
3
Künye
closedAccess
