Preparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing material

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dc.contributor.authorÖztürk, Eylem
dc.contributor.authorAğalar, Cartan
dc.contributor.authorKececi, Kaan
dc.contributor.authorDenkbaş, Emir B.
dc.date.accessioned2020-06-25T17:43:29Z
dc.date.available2020-06-25T17:43:29Z
dc.date.issued2006
dc.descriptionKececi, Kaan/0000-0003-1554-9058; GUVEN, EYLEM/0000-0001-9039-1698
dc.description.abstractThe aim of this study is preparation and characterization of alginate/chitosan sponges including a model antibiotic (i.e., ciprofloxacin) to use in wound and/or burn treatment. Sponges were prepared firstly by the gelation of sodium alginate followed by lyophilization, crosslinking with calcium chloride, and finally coating with chitosan. Sponges were characterized with respect to morphology, water uptake, in vitro drug release behavior, and antimicrobial activity. Investigated and evaluated parameters in all of these studies were selected as the concentration of calcium chloride, alginate viscosity, drug content, and molecular weight of chitosan. Drug release and water uptake were found to be greatly influenced by these parameters. Water uptake and drug release rate were decreased by increasing the crosslinking density, chitosan molecular weight, and alginate viscosity. In the antimicrobial tests, it was obtained that the antimicrobial activity is directly proportional with the release rates and water uptake. Morphological studies showed a highly porous structure with interconnected pores. (c) 2006 Wiley Periodicals, Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/app.23563
dc.identifier.endpage1609en_US
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-33746088816
dc.identifier.scopusqualityQ2
dc.identifier.startpage1602en_US
dc.identifier.urihttps://doi.org10.1002/app.23563
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3731
dc.identifier.volume101en_US
dc.identifier.wosWOS:000238637300049
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalginate spongeen_US
dc.subjectchitosanen_US
dc.subjectwound dressingen_US
dc.subjectciprofloxacin releaseen_US
dc.subjectantimicrobial activityen_US
dc.titlePreparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing materialen_US
dc.typeArticle

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