ADC evaluation of the corticospinal tract in multiple sclerosis

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dc.contributor.authorInal, Mikail
dc.contributor.authorUnal, Birsen
dc.contributor.authorKala, Ibrahim
dc.contributor.authorTurkel, Yakup
dc.contributor.authorBilgili, Yasemin Karadeniz
dc.date.accessioned2020-06-25T18:13:13Z
dc.date.available2020-06-25T18:13:13Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionINAL, MIKAIL/0000-0003-0642-7913
dc.description.abstractApparent diffusion coefficient (ADC) values derived from diffusion-weighted MR imaging (DWI) provide important information about tissues. The goal of this study was to evaluate the ADC values in the corticospinal tract regions in multiple sclerosis (MS). The ADC values of 42 patients with multiple sclerosis and 46 healthy people were measured. The ADC values in the corticospinal tract at the capsula interna posterior crus from six points and mesencephalon from three points bilaterally in MS patients were compared with those of controls. An ANOVA post hoc test was used to analyse the differences in mean ADC values between the MS and control groups. The mean ADC values of the right (p = 0.008) and left internal capsules (p = 0.000) and right (p = 0.002) and left mesencephalons (p = 0.044) in MS patients were significantly lower than in the control group. There was no significant difference between the right and left side ADC values in MS (p = 0.313 vs. p = 0.223) and control groups (p = 0.756 vs. p = 0.105), respectively. The mean ADC values of the corticospinal tract in MS patients were significantly lower than in the control group. This decreased diffusion may be the result of cellular infiltration due to inflammation, cytotoxic oedema, demyelination or remyelination processes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s13760-014-0311-1
dc.identifier.endpage109en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue2en_US
dc.identifier.pmid24878661
dc.identifier.scopus2-s2.0-84929710729
dc.identifier.scopusqualityQ2
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-014-0311-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6152
dc.identifier.volume115en_US
dc.identifier.wosWOS:000354723700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectDiffusion-weighted MRIen_US
dc.subjectMultiple sclerosisen_US
dc.subjectRelapsing-remittingen_US
dc.titleADC evaluation of the corticospinal tract in multiple sclerosisen_US
dc.typeArticle

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