Evaluation of Patients with Fibrotic Interstitial Lung Disease: Preliminary results from the Turk-UIP Study

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dc.authoridAnnakkaya, Ali Nihat/0000-0002-7661-8830
dc.authoridMoğulkoç, Nesrin/0000-0003-1870-5669
dc.authoridÖzgün Niksarlıoğlu, Elif Yelda/0000-0002-6119-6540
dc.authoridAlper, Fatih/0000-0002-9483-8861
dc.authoridAltınışık, Göksel/0000-0001-6869-1301
dc.contributor.authorBenan, Müsellim
dc.contributor.authorNesrin, Moğulkoç
dc.contributor.authorOğuz, Uzun
dc.contributor.authorFatma, Tokgoz Akyil
dc.contributor.authorHaluk, Türktaş
dc.contributor.authorÖzlem, Özdemir Kumbasar
dc.contributor.authorGulfer, Okumus
dc.date.accessioned2025-01-21T16:34:23Z
dc.date.available2025-01-21T16:34:23Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF. MATERIAL AND METHODS: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERSARS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board. RESULTS: A total of 336 patients (253 men, 83 women, age 65.8 +/- 9.0 years) were evaluated. Of the patients with sufficient data for diag-nosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPE None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPE Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively). CONCLUSION: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and EANA positivity reduce the likelihood of IPF.
dc.description.sponsorshipcompany of Roche
dc.description.sponsorshipThis research received unconditional financial support from the company of Roche.
dc.identifier.doi10.5152/TurkThoracJ.2021.20028
dc.identifier.endpage109
dc.identifier.issn2149-2530
dc.identifier.issue2
dc.identifier.pmid33871332
dc.identifier.scopus2-s2.0-85103621219
dc.identifier.scopusqualityN/A
dc.identifier.startpage102
dc.identifier.trdizinid468008
dc.identifier.urihttps://doi.org/10.5152/TurkThoracJ.2021.20028
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay468008
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23960
dc.identifier.volume22
dc.identifier.wosWOS:000659040700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Thoracic Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectFibrotic interstitial lung diseases; idiopathic pulmonary fibrosis; usual interstitial pneumonia
dc.titleEvaluation of Patients with Fibrotic Interstitial Lung Disease: Preliminary results from the Turk-UIP Study
dc.typeArticle

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