Synthesis and characterization of thermo/pH-sensitive pectin-graft-poly (dimethylaminoethyl methacrylate) coated magnetic nanoparticles
Yükleniyor...
Tarih
2020
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, thermo- and pH-sensitive pectin-graft-poly(dimethylaminoethyl methacrylate) copolymer-coated magnetic nanoparticles were synthesized via a green and rapid synthetic approach based on microwave irradiation. Firstly, a novel thermo- and pH-sensitive pectin-graft-poly(dimethylaminoethyl methacrylate) copolymer (Pec-g-PolyDMAEMA) was synthesized and then, Pec-g-PolyDMAEMA based magnetic nanoparticles (Pec-g-PolyDMAEMA@Fe3O4) were produced via microwave-assisted co-precipitation method. The thermo/pH/magnetic field multi-sensitive hybrid nanoparticle was characterized by techniques like TEM, VSM, FT-IR, and TGA/DSC. In vitro release studies of 5-Fluorouracil (FL) were carried out by altering the temperature (37 and 44 degrees C), pH (5.5 and 7.4) and presence of an AMF. The FL release of Pec-g-PolyDMAEMA@Fe3O4@FL exhibited pH-sensitive behavior. They showed thermo/pH-sensitive FL release features with the greatest release of FL at 37 degrees C (56%) than at 44 degrees C (40%) and at pH of 7.4 (63%) than at pH of 5.5 (45%) within 48 h. The FL release was also significantly increased (100%) with the presence of a 50 mT magnetic field. These results indicate that the developed Pec-g-PolyDMAEMA@Fe3O4 nanoparticles are promising in the application of multi-stimuli-sensitive delivery of drugs. (C) 2020 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Magnetic nanoparticle, Thermo/pH-sensitive copolymer, Pectin, Graft copolymerization, Poly(dimethylaminoethyl methacrylate)
Kaynak
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
164
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Künye
closedAccess
