Synthesis and characterization of thermo/pH-sensitive pectin-graft-poly (dimethylaminoethyl methacrylate) coated magnetic nanoparticles

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorPolat, Sevim
dc.date.accessioned2021-01-14T18:10:19Z
dc.date.available2021-01-14T18:10:19Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractHerein, thermo- and pH-sensitive pectin-graft-poly(dimethylaminoethyl methacrylate) copolymer-coated magnetic nanoparticles were synthesized via a green and rapid synthetic approach based on microwave irradiation. Firstly, a novel thermo- and pH-sensitive pectin-graft-poly(dimethylaminoethyl methacrylate) copolymer (Pec-g-PolyDMAEMA) was synthesized and then, Pec-g-PolyDMAEMA based magnetic nanoparticles (Pec-g-PolyDMAEMA@Fe3O4) were produced via microwave-assisted co-precipitation method. The thermo/pH/magnetic field multi-sensitive hybrid nanoparticle was characterized by techniques like TEM, VSM, FT-IR, and TGA/DSC. In vitro release studies of 5-Fluorouracil (FL) were carried out by altering the temperature (37 and 44 degrees C), pH (5.5 and 7.4) and presence of an AMF. The FL release of Pec-g-PolyDMAEMA@Fe3O4@FL exhibited pH-sensitive behavior. They showed thermo/pH-sensitive FL release features with the greatest release of FL at 37 degrees C (56%) than at 44 degrees C (40%) and at pH of 7.4 (63%) than at pH of 5.5 (45%) within 48 h. The FL release was also significantly increased (100%) with the presence of a 50 mT magnetic field. These results indicate that the developed Pec-g-PolyDMAEMA@Fe3O4 nanoparticles are promising in the application of multi-stimuli-sensitive delivery of drugs. (C) 2020 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale UniversityKirikkale University [2020/011]en_US
dc.description.sponsorshipThe authors are thankful to the Scientific Research Projects Coordination Unit of Kirikkale University [Project number: 2020/011] for their financial support.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ijbiomac.2020.09.002
dc.identifier.endpage4515en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid32898537
dc.identifier.scopus2-s2.0-85091044462
dc.identifier.scopusqualityQ1
dc.identifier.startpage4499en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2020.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12507
dc.identifier.volume164en_US
dc.identifier.wosWOS:000588093700428
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIERen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic nanoparticleen_US
dc.subjectThermo/pH-sensitive copolymeren_US
dc.subjectPectinen_US
dc.subjectGraft copolymerizationen_US
dc.subjectPoly(dimethylaminoethyl methacrylate)en_US
dc.titleSynthesis and characterization of thermo/pH-sensitive pectin-graft-poly (dimethylaminoethyl methacrylate) coated magnetic nanoparticlesen_US
dc.typeArticle

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