Tissue expression of glutathione S transferase isoenzymes in vitiligo

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dc.authoridKAYA KOCDOGAN, Arzu/0000-0002-3689-3061
dc.contributor.authorUzuncakmak, Tugba Kevser
dc.contributor.authorOzkanli, Seyma
dc.contributor.authorKocdogan, Arzu Kaya
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorKaradag, Ayse Serap
dc.contributor.authorOzlu, Emin
dc.contributor.authorAkdeniz, Necmettin
dc.date.accessioned2025-01-21T16:55:30Z
dc.date.available2025-01-21T16:55:30Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe association of glutathione S-transferase (GST) enzymes with vitiligo is inconclusive. To evaluate tissue expressions of GST isoenzymes in vitiligo patients and to compare these expressions with healthy controls, we used 26 active depigmented patches on the trunk of vitiligo patients and 20 healthy sex and age matched controls. Punch biopsies were taken from the lesioned or normal skin. Tissue expression of GST isoenzymes were analyzed immunohistochemically. Tissue expression of GSTT1, GSTA1 and GSTP1 was significantly higher in the patient group than controls. Tissue expression of GSTM1 was not significantly different between the two groups. The increased tissue expression of GSTT1, GSTA1 and GSTP1 may represent a response to excess free radical formation in vitiligo and may support the role of oxidative stress in the pathogenesis of vitiligo.
dc.identifier.doi10.1080/10520295.2021.1977998
dc.identifier.endpage321
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5
dc.identifier.pmid34547977
dc.identifier.scopus2-s2.0-85115232607
dc.identifier.scopusqualityQ2
dc.identifier.startpage317
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1977998
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25795
dc.identifier.volume97
dc.identifier.wosWOS:000698255600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAntioxidants; dermatology; glutathione S transferase; human; oxidative stress; pathology; vitiligo
dc.titleTissue expression of glutathione S transferase isoenzymes in vitiligo
dc.typeArticle

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