Value of 18F-fluorodeoxyglucose uptake in positron emission tomography/computed tomography in predicting survival in multiple myeloma

Basit Öğe Kaydı
dc.contributor.authorHaznedar, Rauf
dc.contributor.authorAki, Sahika Z.
dc.contributor.authorAkdemir, Ozgur U.
dc.contributor.authorOzkurt, Zubeyde N.
dc.contributor.authorCeneli, Ozcan
dc.contributor.authorYagci, Munci
dc.contributor.authorUnlu, Mustafa
dc.date.accessioned2020-06-25T17:51:51Z
dc.date.available2020-06-25T17:51:51Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe assessed the role of the maximum standardized uptake value (SUVmax) of bone marrow and the extramedullary lesion with the highest SUVmax in positron emission tomography/computed tomography (PET/CT) of newly diagnosed multiple myeloma (MM) patients in predicting overall survival (OS). A total of 61 newly diagnosed patients (55 MM and 6 plasmacytoma) were enrolled in the study [37 men and 24 women with a median age of 57 years (range 28-80 years)]. The SUVmax of bone marrow and the extramedullary lesion in PET/CT was correlated with the levels of beta(2)-microglobulin, C-reactive protein (CRP), albumin, creatinine, per cent of bone marrow plasma cells, serum free light chain (FLC) ratio, International Staging System (ISS) score and Durie-Salmon stage. The extramedullary lesion with the highest SUVmax showed significant correlation with bone marrow fluorodeoxyglucose (FDG) uptake (p = 0.027) and near significant correlation with ISS (p = 0.048). Bone marrow SUVmax correlated significantly with the per cent of bone marrow plasma cell count (p = 0.024), CRP (p = 0.012) and ISS (p = 0.013). In stage III MM the mean values of SUVmax in extramedullary lesions were significantly higher than stages I and II (6.23 +/- 6.32 vs 2.85 +/- 3.44, p = 0.023). The serum FLC ratio did not show any correlation with SUVmax of lesions and bone marrow (p > 0.05). Forty-four MM patients with FDG-positive lesions in PET/CT showed inferior 5-year estimated survival (61.73%) when compared to 11 patients without FDG-positive lesions, all of whom were alive (p = 0.01). In multivariate analysis an extramedullary lesion with the highest SUVmax was the only independent predictor of OS (p = 0.03). PET/CT allows identification of high-risk myeloma patients, and extramedullary lesions with the highest SUVmax independently predict inferior OS.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00259-011-1738-8
dc.identifier.endpage1053en_US
dc.identifier.issn1619-7070
dc.identifier.issn1619-7089
dc.identifier.issue6en_US
dc.identifier.pmid21287167
dc.identifier.scopus2-s2.0-79958066921
dc.identifier.scopusqualityQ1
dc.identifier.startpage1046en_US
dc.identifier.urihttps://doi.org/10.1007/s00259-011-1738-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5007
dc.identifier.volume38en_US
dc.identifier.wosWOS:000290574100008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Nuclear Medicine And Molecular Imaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple myelomaen_US
dc.subjectPET/CTen_US
dc.subjectSurvivalen_US
dc.titleValue of 18F-fluorodeoxyglucose uptake in positron emission tomography/computed tomography in predicting survival in multiple myelomaen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Value of 18F-fluorodeoxyglucose uptake in positron emission tomography computed tomography in predicting survival in multiple myeloma.pdf
Boyut:
323.55 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu