Helicobacter pylori in bronchiectasis: A polymerase chain reaction assay in bronchoalveolar lavage fluid and bronchiectatic lung tissue

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dc.contributor.authorGülhan, Meral
dc.contributor.authorÖzyılmaz, Ezgi
dc.contributor.authorTarhan, Gülnur
dc.contributor.authorDemirag, Funda
dc.contributor.authorCapan, Nermin
dc.contributor.authorErtürk, Arzu
dc.contributor.authorAhmed, Kamruddin
dc.date.accessioned2020-06-25T17:43:51Z
dc.date.available2020-06-25T17:43:51Z
dc.date.issued2007
dc.descriptionDemirag, Funda/0000-0003-4790-8369; Ahmed, Kamruddin/0000-0002-1869-3701
dc.description.abstractBackground. A number of studies have implicated an association between H. pylori and diverse extra-gastroduodenal pathologies. Chronic inflammation and increased immune response have been observed in bronchiectasis, likely gastroduodenal inflammatory diseases. H. pylori has been found in the trachea-bronchial aspirates of mechanically ventilated patients. Furthermore, the seroprevalence of H. pylori was found to be significantly higher in patients with bronchiectasis than in the control group. The present study was performed to investigate the possible role of H. pylori in the pathogenesis of bronchiectasis. Methods. Prospectively, bronchoalveolar lavage fluid (BALF) was obtained from patients with bronchiectasis (n = 26) and control (n = 20). BALF was subjected to polymerase chain reaction (PCR) to determine the presence of H. pylori and serum IgG against H. pylori was determined with micro-ELISA kit. In addition, PCR was performed to determine H. pylori in surgically removed lung tissues from patients with bronchiectasis (n = 97). Results. H. pylori DNA was not detected in the BALF or in lung tissue samples. In addition, anti-H. pylori IgG level in patients with bronchiectasis did not show statistically significant difference from that of the control. Conclusions. Our study provided evidence that there might be no direct association between H. pylori and bronchiectasis; however, the indirect role of soluble products of H. pylori could not be excluded. (C) 2007 IMSS. Published by Elsevier Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.arcmed.2006.11.010
dc.identifier.endpage321en_US
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue3en_US
dc.identifier.pmid17350482
dc.identifier.scopus2-s2.0-33847683800
dc.identifier.scopusqualityQ1
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org10.1016/j.arcmed.2006.11.010
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3925
dc.identifier.volume38en_US
dc.identifier.wosWOS:000245449400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives Of Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbronchiectasisen_US
dc.subjectbronchoalveaolar lavage fluiden_US
dc.subjectHelicobacter pylorien_US
dc.subjectlung tissueen_US
dc.subjectPCR assayen_US
dc.titleHelicobacter pylori in bronchiectasis: A polymerase chain reaction assay in bronchoalveolar lavage fluid and bronchiectatic lung tissueen_US
dc.typeArticle

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