Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats

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dc.contributor.authorGökçe, Emre Cemal
dc.contributor.authorKahveci, Ramazan
dc.contributor.authorAtanur, Osman Malik
dc.contributor.authorGürer, Bora
dc.contributor.authorAksoy, Nurkan
dc.contributor.authorGökçe, Aysun
dc.contributor.authorKahveci, Ozan
dc.date.accessioned2020-06-25T18:12:43Z
dc.date.available2020-06-25T18:12:43Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionGurer, Bora/0000-0003-1500-6184; Sargon, Mustafa Fevzi/0000-0001-6360-6008
dc.description.abstractIntroduction: Ganoderma lucidum (G. lucidum) is a mushroom belonging to the polyporaceae family of Basidiomycota and has widely been used as a traditional medicine for thousands of years. G. lucidum has never been studied in traumatic spinal cord injury. The aim of this study is to investigate whether G. lucidum polysaccharides (GLPS) can protect the spinal cord after experimental spinal cord injury. Materials and methods: Rats were randomized into five groups of eight animals each: control, sham, trauma, GLPS, and methylprednisolone. In the control group, no surgical intervention was performed. In the sham group, only a laminectomy was performed. In all the other groups, the spinal cord trauma model was created by the occlusion of the spinal cord with an aneurysm clip. In the spinal cord tissue, caspase-3 activity, tumour necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, nitric oxide levels, and superoxide dismutase levels were analysed. Histopathological and ultrastructural evaluations were also performed. Neurological evaluation was performed using the Basso, Beattie, and Bresnahan locomotor scale and the inclined-plane test. Results: After traumatic spinal cord injury, increases in caspase-3 activity, tumour necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, and nitric oxide levels were detected. After the administration of GLPS, decreases were observed in tissue caspase-3 activity, tumour necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, and nitric oxide levels. Furthermore, GLPS treatment showed improved results in histopathological scores, ultrastructural scores, and functional tests. Conclusions: Biochemical, histopathological, and ultrastructural analyses and functional tests reveal that GLPS exhibits meaningful neuroprotective effects against spinal cord injury. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.injury.2015.08.017
dc.identifier.endpage2155en_US
dc.identifier.issn0020-1383
dc.identifier.issn1879-0267
dc.identifier.issue11en_US
dc.identifier.pmid26298021
dc.identifier.scopus2-s2.0-84947037017
dc.identifier.scopusqualityQ1
dc.identifier.startpage2146en_US
dc.identifier.urihttps://doi.org/10.1016/j.injury.2015.08.017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6018
dc.identifier.volume46en_US
dc.identifier.wosWOS:000363901600010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInjury-International Journal Of The Care Of The Injured
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGanoderma lucidumen_US
dc.subjectMethylprednisoloneen_US
dc.subjectNeuroprotectionen_US
dc.subjectPolysaccharidesen_US
dc.subjectSpinal cord injuryen_US
dc.subjectTraumaen_US
dc.titleNeuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in ratsen_US
dc.typeArticle

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