Effects of melatonin and dexpanthenol on antioxidant parameters when combined with estrogen treatment in ovariectomized rats

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dc.contributor.authorTurgut, Ozan
dc.contributor.authorAy, Aybala Agac
dc.contributor.authorTurgut, Hulya
dc.contributor.authorAy, Ahmet
dc.contributor.authorKafkas, Samet
dc.contributor.authorDost, Turhan
dc.date.accessioned2020-06-25T18:06:56Z
dc.date.available2020-06-25T18:06:56Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionTiwari, Prafulla/0000-0001-7913-5386
dc.description.abstractThe purpose of the study was to assess whether it is possible to reduce the oxidative damage using antioxidant agents combined with hormone replacement therapy after menopause. In this prospective experimental study, 50 mature female Wistar albino rats weighing 270-310 g were used. Rats were divided into the following six groups: (1) Ovx group (n = 7): the animals underwent bilateral ovariectomy. No drug was administered following bilateral ovariectomy. (2) Ovx + E (2) group (n = 7): bilateral ovariectomy + 17 beta-estradiol (100 mu g/kg/day); (3) Ovx + E (2) + MT5 group (n = 7): bilateral ovariectomy + 17 beta-estradiol (100 mu g/kg/day) + melatonin (5 mg/kg/day); (4) Ovx + E (2) + MT20 group (n = 7): bilateral ovariectomy + 17 beta-estradiol (100 mu g/kg/day) + melatonin (20 mg/kg/day); (5) Ovx + E (2) + Dxp250 group (n = 7): bilateral ovariectomy + 17 beta-estradiol (100 mu g/kg/day) + dexpanthenol (250 mg/kg/day); (6) Ovx + E (2) + Dxp500 group (n = 7): bilateral ovariectomy + 17 beta-estradiol (100 mu g/kg/day) + dexpanthenol (500 mg/kg/day), and the activity of these antioxidative enzymes and oxidative stress products were measured. Enzymatic activity levels of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase(GSH-Px), and glutathione reductase and levels of free radicals (malondialdehyde (MDA) and nitric oxide) were both analyzed. We observed an increase in the level of GSH activity, but no significant differences in levels of CAT, SOD, and GSH-Px enzymatic activity and in levels of free radical MDA following 17 beta-estradiol or additional antioxidant treatment (melatonin or dexpanthenol). Despite the present study indicating that the addition of melatonin and dexpanthenol into the hormone replacement therapy regimen may contribute to the antioxidant effect of estrogen, the existence of limited data in this field indicates that further studies are warranted.en_US
dc.identifier.citationTurgut, O., Ay, A. A., Turgut, H., Ay, A., Kafkas, S., & Dost, T. (2013). Effects of melatonin and dexpanthenol on antioxidant parameters when combined with estrogen treatment in ovariectomized rats. Age (Dordrecht, Netherlands), 35(6), 2229–2235.en_US
dc.identifier.doi10.1007/s11357-013-9519-x
dc.identifier.endpage2235en_US
dc.identifier.issn0161-9152
dc.identifier.issn1574-4647
dc.identifier.issue6en_US
dc.identifier.pmid23471492
dc.identifier.scopus2-s2.0-84892513009
dc.identifier.scopusqualityN/A
dc.identifier.startpage2229en_US
dc.identifier.urihttps://doi.org/10.1007/s11357-013-9519-x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5419
dc.identifier.volume35en_US
dc.identifier.wosWOS:000326100600017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofAge
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMenopauseen_US
dc.subjectOxidative stressen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectHormone replacement therapyen_US
dc.subjectAntioxidant agentsen_US
dc.titleEffects of melatonin and dexpanthenol on antioxidant parameters when combined with estrogen treatment in ovariectomized ratsen_US
dc.typeArticle

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