The relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitis

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dc.contributor.authorKultur, Turgut
dc.contributor.authorOztas, Dilek
dc.contributor.authorKeskin, Dilek
dc.contributor.authorKeskin, Goksal
dc.contributor.authorInal, Ali
dc.contributor.authorKara, Halil
dc.date.accessioned2020-06-25T18:34:23Z
dc.date.available2020-06-25T18:34:23Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: The aim of this study was to investigate the relationship between serum vitamin D receptor (SVDR) levels and disease activity parameters in patients with ankylosing spondylitis (AS). Patients and methods: Between July 2016 and January 2017, a total of 62 patients (51 males, 11 females; mean age 36.5 +/- 12.8 years; range, 23 to 49 years) with AS and 32 healthy volunteers (25 males, 7 females; mean age 41.57 +/- 13.6 years; range, 26 to 48 years) were included in the study. The SVDR levels were measured using the enzyme-linked immunosorbent assay. Erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) levels were recorded. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were used to assess disease activity. Results: Although there was no significant difference between the patient and control groups (p=0.66), SVDR levels were significantly elevated in patients with active AS (BASDAI score >= 4) (p=0.01). The SVDR levels significantly increased in AS patients with peripheral joint involvement and enthesitis (p=0.01, p=0.05, respectively). The SVDR levels significantly elevated in patients treated with non-steroidal anti-inflammatory drugs, compared to those treated with biological agents and control group (p=0.01, p=0.03, respectively). The SVDR levels were positively correlated with the BASDAI, CRP and ESR in the patient group (p=0.01, r=0.751; p=0.01, r=0.75; p=0.01, r=0.81, respectively). Conclusion: Our study results suggest that serum SVDR levels are associated with the disease activity and clinical parameters in patients with AS. Based on these findings, SVDR level may be used as a marker of disease activity in AS.en_US
dc.identifier.citationKültür T, Öztaş D, Keskin D, Keskin G, İnal A, Kara H. The relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitis. Turk J Phys Med Rehabil. 2019 Nov 22;65(4):389-393.en_US
dc.identifier.doi10.5606/tftrd.2019.3296
dc.identifier.endpage393en_US
dc.identifier.issn2587-0823
dc.identifier.issue4en_US
dc.identifier.pmid31893276
dc.identifier.scopus2-s2.0-85078938581
dc.identifier.scopusqualityQ2
dc.identifier.startpage389en_US
dc.identifier.trdizinid382196
dc.identifier.urihttps://doi.org/10.5606/tftrd.2019.3296
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7893
dc.identifier.volume65en_US
dc.identifier.wosWOS:000511167800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurkish Journal Of Physical Medicine And Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectclinical and laboratory parametersen_US
dc.subjectserum vitamin D receptoren_US
dc.titleThe relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitisen_US
dc.typeArticle

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