In vitro antimicrobial activity of commonly used vasoactive drugs

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dc.contributor.authorApan, Ozgun Cuvas
dc.contributor.authorApan, Teoman Zafer
dc.contributor.authorApan, Alparslan
dc.date.accessioned2020-06-25T18:16:07Z
dc.date.available2020-06-25T18:16:07Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractStudy Objective: Microbial contamination during preparation of the infusion drugs is an important issue in intensive care units. Objective of this study was to investigate in vitro antimicrobial properties of commonly used vasoactive drugs. Design: Prospective study. Setting: Clinical microbiology laboratory of a university hospital. Measurements: Growth of the microorganisms Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans in saline dilutions of adrenaline at 1, 10, and 100 mu g/mL; noradrenaline at 1, 10, and 100 mu g/mL; and dopamine at 0.1, 1, and 10 mg/mL concentrations was investigated. Each drug solution and saline were analyzed with a digital pH meter. Main Results: Saline dilutions of adrenaline, noradrenaline, and dopamine at clinically used concentrations decreased microbial growth. The highest concentration doses of adrenaline, noradrenaline, and dopamine used in the study had significant antimicrobial effect when compared to the low and moderate doses. This effect was shown with the all microorganisms. S aureus, S epidermidis, and C albicans were more sensitive; on the other hand, E coli and P aeruginosa were more resistant against the effect of the drug dilutions. Conclusions: To limit microbial growth in case of contamination of the drug solution, it is advisable to use more concentrated dilutions of adrenaline, noradrenaline, and dopamine used in clinical practice. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jclinane.2016.05.008
dc.identifier.endpage411en_US
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.pmid27687422
dc.identifier.scopus2-s2.0-84973521593
dc.identifier.scopusqualityQ1
dc.identifier.startpage407en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2016.05.008
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6425
dc.identifier.volume34en_US
dc.identifier.wosWOS:000384952700087
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Clinical Anesthesia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial activitiesen_US
dc.subjectCatecholamineen_US
dc.subjectDrug contaminationen_US
dc.subjectInfusionen_US
dc.titleIn vitro antimicrobial activity of commonly used vasoactive drugsen_US
dc.typeArticle

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