The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

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dc.contributor.authorKocakap, Derya Beyza Sayin
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorSimsek, Vedat
dc.contributor.authorCabuk, Feryal
dc.contributor.authorYildirim, Nesligul
dc.contributor.authorCelik, Yunus
dc.contributor.authorErdem, Solmaz
dc.date.accessioned2020-06-25T18:16:44Z
dc.date.available2020-06-25T18:16:44Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Coronary artery disease (CAD) is a common, complex, and progressive disorder characterized by the accumulation of lipids and fibrous elements in the arteries. It is one of the leading causes of death in industrialized nations. Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays an important role in the initiation and progression of atherosclerosis. Paraoxonase1 (PON1) is involved in lipid metabolism and is believed to protect LDL oxidation. In our study, we aimed to clarify the relationship between PON1 gene L55M polymorphism and the extent and severity of CAD. Methods: In total, 114 patients (54 males, mean age: 56.7 +/- 12.0 years; 60 females, mean age: 55.7 +/- 13.2 years) with stable angina or angina equivalent symptoms were enrolled in this prospective study. Cardiological evaluation was performed with electrocardiogram and transthoracic echocardiogram. The presence of hypertension, dyslipidemia, diabetes, and smoking status were ascertained. The patients were grouped according to their Gensini scores and gender. Genetic analysis of the PON1 gene L55M polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: We determined that the LL genotype was more prevalent in patients with Gensini score higher than or equal to 20 (p=0.026) and that this correlated with severe atherosclerotic coronary artery lesions in both gender groups, reaching a statistical significance in the female subjects (p=0.038). Conclusion: It was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination UnitKirikkale University [2009/27]en_US
dc.description.sponsorshipThe study was supported through a grant (2009/27) by Kirikkale University Scientific Research Projects Coordination Unit.en_US
dc.identifier.citationKocakap D. B. S., Doğru M. T., Şimşek V., Çabuk F., Yıldırım N., Çelik Y., Alyılmaz S. B., Erdem S. (2016). The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. The Anatolian Journal of Cardiology, 16(3), 175 - 182.en_US
dc.identifier.doi10.5152/akd.2015.6010
dc.identifier.endpage182en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3en_US
dc.identifier.pmid26467378
dc.identifier.scopus2-s2.0-84994319470
dc.identifier.scopusqualityQ3
dc.identifier.startpage175en_US
dc.identifier.trdizinid199542
dc.identifier.urihttps://doi.org/10.5152/akd.2015.6010
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6610
dc.identifier.volume16en_US
dc.identifier.wosWOS:000377193000007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectparaoxonase1en_US
dc.subjectcoronary artery diseaseen_US
dc.subjectatherosclerosisen_US
dc.subjectL55M polymorphismen_US
dc.titleThe association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on genderen_US
dc.typeArticle

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