Protective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity in rats

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dc.contributor.authorAtmaca, Nurgul
dc.contributor.authorAtmaca, Hasan Tarik
dc.contributor.authorKanici, Ayse
dc.contributor.authorAnteplioglu, Tugce
dc.date.accessioned2020-06-25T18:12:09Z
dc.date.available2020-06-25T18:12:09Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionDas, Kusal/0000-0002-3641-2117; ATMACA, HASAN TARIK/0000-0001-8379-4114
dc.description.abstractProtective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity were studied in rats. A total of 28 Wistar albino male rats were used. Four study groups were randomly formed with seven animals in each. The groups were treated for 21 days with distilled water (control group), with water containing 100 ppm fluoride (fluoride group), with resveratrol (12.5 mg/kg i.p., resveratrol group), or with 100 ppm fluoride + 12.5 mg/kg resveratrol i.p. (fluoride + resveratrol group). At the end of the trial, blood samples were collected by cardiac puncture and tissue samples were taken simultaneously. The total antioxidant and oxidant status in plasma and tissues as well as plasma 8-hydroxydeoxyguanosine levels were measured. Histopathological analyses of rat liver and brain tissues were performed in all groups to identify any changes. In the fluoride group, the total oxidant levels increased in plasma, liver and brain and total antioxidant levels decreased, as did the plasma 8-hydroxy-deoxyguanosine levels. These changes were prevented by co-administration of resveratrol. In addition, fluoride-associated severe histopathological changes in brain and liver tissues were not observed in the fluoride + resveratrol group. Consequently, these data suggested that resveratrol had beneficial effects in alleviating fluoride-induced oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipKirikkale University Research FundKirikkale University [2011/44]en_US
dc.description.sponsorshipFinancial support for this Project (Project No: 2011/44) was provided by the Kirikkale University Research Fund.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.fct.2014.05.011
dc.identifier.endpage197en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid24857819
dc.identifier.scopus2-s2.0-84902166593
dc.identifier.scopusqualityQ1
dc.identifier.startpage191en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2014.05.011
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5770
dc.identifier.volume70en_US
dc.identifier.wosWOS:000339599800025
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood And Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluoride toxicityen_US
dc.subjectOxidative stressen_US
dc.subjectLiveren_US
dc.subjectBrainen_US
dc.subjectResveratrolen_US
dc.subjectRatsen_US
dc.titleProtective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity in ratsen_US
dc.typeArticle

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