Effects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study

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dc.contributor.authorYakaryilmaz, F.
dc.contributor.authorGuliter, S.
dc.contributor.authorSavaş, B.
dc.contributor.authorErdem, O.
dc.contributor.authorErsoy, R.
dc.contributor.authorErden, E.
dc.contributor.authorÖzenirler, S.
dc.date.accessioned2020-06-25T17:43:52Z
dc.date.available2020-06-25T17:43:52Z
dc.date.issued2007
dc.descriptionErdem, Ayhan/0000-0001-7761-1078
dc.description.abstractBackground: Insulin resistance (IR) is commonly associated with non-alcoholic steatohepatitis (NASH). Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) may also play a role in the pathogenesis of NASH. A pivotal role in NASH pathogenesis depends on the hypothesis of increased oxidative stress. The aim of our study was to evaluate the effects of supplemental oral vitamin E, a potent antioxidant, on liver functions, PPAR-alpha expression and IR in patients with NASH. Methods: Nine patients with biopsy-proven NASH were given oral vitamin E 800 mg daily for 24 weeks. Liver functions, lipid parameters, IR index with homeostatic metabolic assessment and liver histology and PPAR-alpha staining index in biopsy specimens were detected before and after the treatment. Results: Seven patients (78%) had IR initially. After 6 months of therapy in nine patients, fasting insulin improved (P = 0.01), but serum cholesterol, triglyceride, fasting blood glucose levels and body mass index remained unchanged. Aspartate aminotransferase and alanine aminotransferase levels decreased (P = 0.01 and P = 0.01, respectively). IR index with homeostatic metabolic assessment resistance improved (P = 0.01), but PPAR-alpha staining index did not change (P = 0.37). Although the histological grade of steatosis decreased (P = 0.01), necroinflammation and fibrosis remained unchanged. In seven patients with IR, however, necroinflammation and PPAR-alpha staining index were improved (P = 0.04 and P = 0.02). Conclusion: Vitamin E treatment, in addition to its previously shown beneficial effect by suppressing oxidative stress, may also achieve improvement by reducing IR and PPAR-alpha expression in NASH.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1445-5994.2006.01295.x
dc.identifier.endpage235en_US
dc.identifier.issn1444-0903
dc.identifier.issn1445-5994
dc.identifier.issue4en_US
dc.identifier.pmid17388862
dc.identifier.scopus2-s2.0-33947400987
dc.identifier.scopusqualityQ2
dc.identifier.startpage229en_US
dc.identifier.urihttps://doi.org10.1111/j.1445-5994.2006.01295.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3930
dc.identifier.volume37en_US
dc.identifier.wosWOS:000245057300004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofInternal Medicine Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnon-alcoholic steatohepatitisen_US
dc.subjectinsulin resistanceen_US
dc.subjectperoxisome proliferator-activated receptor-alphaen_US
dc.subjectvitamin Een_US
dc.titleEffects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot studyen_US
dc.typeArticle

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