Role of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic rats

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dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorYildirim, Serkan
dc.contributor.authorKul, Oguz
dc.date.accessioned2020-06-25T18:30:16Z
dc.date.available2020-06-25T18:30:16Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionDINCEL, Gungor Cagdas/0000-0002-6985-3197
dc.description.abstractType 1 diabetes mellitus (T1DM) is a severe chronic metabolic disorder characterized by hyperglycaemia because of the alterations in insulin secretion or its action. It is previously shown that hyperglycemia related oxidative stress (OS) and excessive nitric oxide (NO) production may cause severe complications in kidney and brain. In this report, it is aimed to investigate the cytotoxic effects of NO and to evaluate possible interaction with T1DM related hepatopathology. Expression levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), Cu/Zn superoxide dismutase (SOD1) and glutathione reductase (GR) were examined by immunohistochemistry in liver tissues. Results of the study revealed that levels of 8-OHdG (P<0.001), eNOS (P<0.001), eNOS (P<0.001), SOD1 (P<0.001) and GR (P<0.001) were remarkably higher in liver with T1DM than control. The most prominent finding of this study is the increased levels of 8-OHdG in the mostly hepatocyte cytoplasm. These results suggest an involvement of oxidative DNA damage and OS might play a pivotal role on hepatic degeneration and this is a novel insight of pathogenesis on the explanation of cellular processes in streptozotocin (STZ)-induced type 1 diabetic rats'liver. Furthermore, these results also suggested that STZ-induced hepatic pathology might have been augmented by the contribution of high NO expression mediated OS. Taken together, the results suggest NO related hepatic inflammation and degeneration closely implicated in pathophysiology of T1DM. The results also clearly indicated that OS plays an important role on hepatic pathology and OS biomarkers might indicate the progress of the T1DM.en_US
dc.description.sponsorshipScientific Research Projects Commission of the Gumushane University, TurkeyGumushane University [15.B0421.02.2]en_US
dc.description.sponsorshipThis work was funded and supported by the Scientific Research Projects Commission of the Gumushane University, Turkey (Project Code: 15.B0421.02.2). This study was presented as an oral presentation in the 32nd World Veterinary Congress, 13-17 September 2015, Istanbul.en_US
dc.identifier.citationDinçel, G. Ç. , Yıldırım, S. & Kul, O. (2018). Role of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic rats . Ankara Üniversitesi Veteriner Fakültesi Dergisi , 65 (1) , 39-50.en_US
dc.identifier.doi10.1501/Vetfak_0000002825
dc.identifier.endpage50en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85037059493
dc.identifier.scopusqualityQ3
dc.identifier.startpage39en_US
dc.identifier.trdizinid271363
dc.identifier.urihttps://doi.org/10.1501/Vetfak_0000002825
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7602
dc.identifier.volume65en_US
dc.identifier.wosWOS:000416989900006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatopathologyen_US
dc.subjectnitric oxideen_US
dc.subjectoxidative stressen_US
dc.subjecttype 1 diabetes mellitusen_US
dc.titleRole of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic ratsen_US
dc.typeArticle

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