Diagnostic implications of telomerase activity in pleural effusions

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dc.contributor.authorDikmen, G.
dc.contributor.authorDikmen, E.
dc.contributor.authorKara, M.
dc.contributor.authorŞahin, E.
dc.contributor.authorDogan, P.
dc.contributor.authorÖzdemir, N.
dc.date.accessioned2020-06-25T17:35:21Z
dc.date.available2020-06-25T17:35:21Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of the present study was to investigate the diagnostic efficacy of telomerase activity for discrimination of malignant and benign pleural effusions. Pleural effusions were collected from 109 consecutive patients in whom the diagnosis was confirmed with cytological and/or histological examinations. Cytological samples were classified as malignant (n=63) and benign (n=46). Telomerase activity was determined with the polymerase chain reaction-based telomeric repeat amplification protocol assay. Telomerase activity was detected in 52 (82.5%) and nine (19.6%) samples from the malignant and benign groups, respectively, which was a significant difference. The sensitivity rate of cytological examination when combined with telomerase activity (92.1%) was significantly greater than that of cytological examination alone (53.9%). The sensitivity and specificity of telomerase activity were 82.5 and 80.4%, respectively. Diagnostic accuracy of telomerase activity was 81.6%. Telomerase activity is a highly sensitive diagnostic biomarker for malignancy and may be used as an adjunct to cytological findings in determining malignant pleural effusions.en_US
dc.identifier.citationDikmen, G., Dikmen, E., Kara, M., Sahin, E., Doğan, P., & Ozdemir, N. (2003). Diagnostic implications of telomerase activity in pleural effusions. The European respiratory journal, 22(3), 422–426. https://doi.org/10.1183/09031936.03.00001303en_US
dc.identifier.doi10.1183/09031936.03.00001303
dc.identifier.endpage426en_US
dc.identifier.issn0903-1936
dc.identifier.issue3en_US
dc.identifier.pmid14516130
dc.identifier.scopus2-s2.0-0042881125
dc.identifier.scopusqualityQ1
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.1183/09031936.03.00001303
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3096
dc.identifier.volume22en_US
dc.identifier.wosWOS:000185339400008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEuropean Respiratory Soc Journals Ltden_US
dc.relation.ispartofEuropean Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpleural effusionen_US
dc.subjectmalignancyen_US
dc.subjecttelomeraseen_US
dc.titleDiagnostic implications of telomerase activity in pleural effusionsen_US
dc.typeArticle

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