Bcl-2-related proteins, (alpha)-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas

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dc.contributor.authorBozdoğan, Ö.
dc.contributor.authorErkek, E.
dc.contributor.authorAtasoy, P.
dc.contributor.authorKoçak, M.
dc.contributor.authorBirol, A.
dc.contributor.authorCaydere, M.
dc.date.accessioned2020-06-25T17:34:57Z
dc.date.available2020-06-25T17:34:57Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAberrant expression of bcl-gene products has been implicated in the development of non-melanoma skin cancers. Recently, altered expression of alpha-smooth muscle actin has been proposed as predictive of tumour behaviour in basal cell carcinomas. The purpose of this study was to compare the aggressive and non-aggressive basal cell carcinomas in terms of bcl-gene products and alpha-smooth muscle actin expression. Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl-2, bax, bcl-x and alpha-smooth muscle actin. Bcl-2, bcl-x and bax were expressed in 34 (68%), 38 (76%) and 41 (82%) specimens, respectively. Immunoreactivity for alpha-smooth muscle actin was noted both in tumour nests (64%) and within the stroma (54%). There was a significant difference between aggressive and non-aggressive basal cell carcinomas in terms of bcl-2 and stromal alpha-smooth muscle actin immunoreactivity. Non-aggressive basal cell carcinomas display a concordant expression of bcl-family proteins, whereas aggressive tumours reveal a discordant pattern. An increased expression of stromal alpha-smooth muscle actin with a concomitant decrease or loss of bcl-2 expression may be highly suggestive of aggressiveness in basal cell carcinoma.en_US
dc.identifier.citationBozdogan, O., Erkek, E., Atasoy, P., Koçak, M., Birol, A., & Caydere, M. (2002). Bcl-2-related proteins, alpha-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas. Acta dermato-venereologica, 82(6), 423–427. https://doi.org/10.1080/000155502762064548en_US
dc.identifier.doi10.1080/000155502762064548
dc.identifier.endpage427en_US
dc.identifier.issn0001-5555
dc.identifier.issue6en_US
dc.identifier.pmid12575847
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.1080/000155502762064548
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2961
dc.identifier.volume82en_US
dc.identifier.wosWOS:000180345700004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofActa Dermato-Venereologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbasal cell carcinomaen_US
dc.subjectamyloiden_US
dc.subjectapoptosisen_US
dc.subjectbcl-2en_US
dc.subjectbaxen_US
dc.subjectbcl-xen_US
dc.subjectmyofibroblasten_US
dc.titleBcl-2-related proteins, (alpha)-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomasen_US
dc.typeArticle

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