Dexmedetomidine as an Alternative Anesthetic Agent for Flap Surgery: An Intravital Evaluation in the Cremaster Muscle Flap

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dc.contributor.authorGencay, Isin
dc.contributor.authorBoybeyi, Ozlem
dc.contributor.authorUnlu, Gulhan
dc.contributor.authorYazici, Ilker
dc.contributor.authorAydin, Gulcin
dc.contributor.authorBuyukkocak, Unase
dc.date.accessioned2020-06-25T18:30:26Z
dc.date.available2020-06-25T18:30:26Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: Flap surgery is one of the most commonly used techniques of reconstructive surgery for effective repair of damaged tissue. Optimal anesthetic technique and anesthetic agent plays an important role in flap perfusion. This study aimed to evaluate the effects of dexmedetomidine infusion on the microcirculation in the cremaster muscle flap by direct in vivo monitoring. Materials and Methods: We randomly divided 9 Wistar albino rats into 3 groups. The rats in the control group underwent the surgical procedure (isolation of the cremaster muscle) alone; the rats in the experimental groups 1 and 2 received an infusion of dexmedetomidine (10 and 30 min) after the surgical procedure. Results: The means of vessel diameters, number of functional capillaries, and movements of leukocytes in all groups were evaluated using intravital microscopic examination. The diameters of the arterioles and venules of the cremaster muscle significantly increased in the dexmedetomidine groups. The number of functional capillaries was higher in the dexmedetomidine groups than in the control group. No difference was observed in the movements of leukocytes between the control and experimental groups. Dexmedetomidine significantly increased the diameters of the arterioles and venules of the cremaster flap and the number of functional capillaries. Conclusion: On the basis of the effects of dexmedetomidine on microcirculation, we suggest that dexmedetomidine continue to be used as an anesthetic agent, and may be considered also for reconstructive procedures, particularly flap surgery.en_US
dc.description.sponsorshipKirikkale University Faculty of MedicineKirikkale Universityen_US
dc.description.sponsorshipThis study was supported by the Kirikkale University Faculty of Medicine.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/SCS.0000000000005850
dc.identifier.endpage2472en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue8en_US
dc.identifier.pmid31469734
dc.identifier.scopus2-s2.0-85071688473
dc.identifier.scopusqualityQ3
dc.identifier.startpage2469en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000005850
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7642
dc.identifier.volume30en_US
dc.identifier.wosWOS:000509687200084
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectflap surgeryen_US
dc.subjectmicrocirculationen_US
dc.titleDexmedetomidine as an Alternative Anesthetic Agent for Flap Surgery: An Intravital Evaluation in the Cremaster Muscle Flapen_US
dc.typeArticle

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