Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A novel resourceful bulk poly(Tannic Acid) (p(TA)) hydrogel was prepared by crosslinking TA molecules with an epoxy crosslinker, trimethylolpropane triglycidyl ether (TMPGDE), in an autoclave at 90 degrees C for 2 h. The obtained p(TA) hydrogels were in disk form and have highly porous morphology. The swelling characteristics of p(TA) hydrogels were investigated in wound healing pH conditions of pH 5.4, 7.4, and 9 at 37.5 degrees C, and the hydrogels showed good swelling and moisture content behavior. Especially, p(TA) hydrogels were found to be sensitive to pH 9 with 1669% maximum swelling. P(TA) hydrogels were completely degraded at pH 9 hydrolytically in 9 days. Total phenol contents and the effects of scavenging ABTS radicals of degraded p(TA) hydrogels at pH 5.4, 7.4, and 9 were evaluated and calculated in terms of gallic acid equivalent and trolox equivalent antioxidant capacity, respectively, and found to be very effective. Moreover, degraded p(TA) hydrogels display strong antimicrobial behavior against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Pseudomonas aeruginosa bacteria strains and Candida albicans fungus strain. The WST-1 results indicated that bulk p(TA) hydrogels have no cyctotoxicity to the L929 fibroblast cell line in vitro. (C) 2015 Elsevier B.V. All rights reserved.
Açıklama
Silan, Coskun/0000-0002-8352-6571; silan, coskun/0000-0002-8352-6571; Sahiner, Nurettin/0000-0003-0120-530X; Aktas, Nahit/0000-0001-9341-607X; Sagbas Suner, Selin/0000-0002-3524-0675; sahiner, mehtap/0000-0001-8666-7954
Anahtar Kelimeler
Tannic acid, Antimicrobial/antioxidant hydrogel, Biodegradable/biocompatible superporous film
Kaynak
International Journal Of Biological Macromolecules
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
82
Sayı
Künye
closedAccess
