Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties

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dc.contributor.authorSahiner, Nurettin
dc.contributor.authorSagbas, Selin
dc.contributor.authorSahiner, Mehtap
dc.contributor.authorSilan, Coskun
dc.contributor.authorAktas, Nahit
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:22:32Z
dc.date.available2020-06-25T18:22:32Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionSilan, Coskun/0000-0002-8352-6571; silan, coskun/0000-0002-8352-6571; Sahiner, Nurettin/0000-0003-0120-530X; Aktas, Nahit/0000-0001-9341-607X; Sagbas Suner, Selin/0000-0002-3524-0675; sahiner, mehtap/0000-0001-8666-7954
dc.description.abstractA novel resourceful bulk poly(Tannic Acid) (p(TA)) hydrogel was prepared by crosslinking TA molecules with an epoxy crosslinker, trimethylolpropane triglycidyl ether (TMPGDE), in an autoclave at 90 degrees C for 2 h. The obtained p(TA) hydrogels were in disk form and have highly porous morphology. The swelling characteristics of p(TA) hydrogels were investigated in wound healing pH conditions of pH 5.4, 7.4, and 9 at 37.5 degrees C, and the hydrogels showed good swelling and moisture content behavior. Especially, p(TA) hydrogels were found to be sensitive to pH 9 with 1669% maximum swelling. P(TA) hydrogels were completely degraded at pH 9 hydrolytically in 9 days. Total phenol contents and the effects of scavenging ABTS radicals of degraded p(TA) hydrogels at pH 5.4, 7.4, and 9 were evaluated and calculated in terms of gallic acid equivalent and trolox equivalent antioxidant capacity, respectively, and found to be very effective. Moreover, degraded p(TA) hydrogels display strong antimicrobial behavior against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Pseudomonas aeruginosa bacteria strains and Candida albicans fungus strain. The WST-1 results indicated that bulk p(TA) hydrogels have no cyctotoxicity to the L929 fibroblast cell line in vitro. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z238]en_US
dc.description.sponsorshipThis work is supported by The Scientific and Technological Research Council of Turkey (113Z238).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ijbiomac.2015.10.057
dc.identifier.endpage159en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid26526171
dc.identifier.scopus2-s2.0-84951767677
dc.identifier.scopusqualityQ1
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2015.10.057
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6792
dc.identifier.volume82en_US
dc.identifier.wosWOS:000367425100020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal Of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTannic aciden_US
dc.subjectAntimicrobial/antioxidant hydrogelen_US
dc.subjectBiodegradable/biocompatible superporous filmen_US
dc.titleBiocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant propertiesen_US
dc.typeArticle

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