Prevalence of occult hepatitis B and hepatitis C virus infections in Turkish hemodialysis patients
Yükleniyor...
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and Objective. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are important causes of morbidity and mortality in maintenance hemodialysis patients. Although their exact prevalence is not known, HBV and HCV viral infections and occult viral hepatitis are frequent in these patients. This study aimed to determine the prevalence of occult HBV and HCV infections in maintenance hemodialysis patients. Materials and Methods. One hundred and eighty-eight end-stage renal disease patients on maintenance hemodialysis (100 male, mean age 49 29 [16-80] years, and mean duration of hemodialysis 98 66 [12-228] months) were enrolled in this study. Scrological markers for HBV and HCV were determined with immunoenzymatic assay (ELISA) by using commercial diagnostic kits (Access and BioRad, Beckman-Coulter). HCV-RNA (Cobas Amplicor HCV kit) and HBV-DNA (Artus GmbH HBV kit) were determined quantitatively by polymerase chain reaction. Results. Among the patients screened, 25 (13.3%) had HBV infection alone and 38 (20.2%) had HCV infection alone, while seven (3.7%) had dual infection of both viruses. Serological markers for occult hepatitis B and occult hepatitis C were positive in five (2.7%) and nine (4.8%) of the patients, respectively. Isolated anti-HBc was positive in 12 (6.4%) of all patients, three (7.9%) of the patients with anti-HCV and two (40%) of the patients with occult hepatitis B. Isolated anti-HBc positivity was more frequent in patients with occult hepatitis B than in those without (40% [2/5] vs. 5.5% [10/183], p=0.002). None of the patients with HCV had occult hepatitis B. Conclusions. Both occult and non-occult forms of HCV infection are more prevalent than HBV infection in hemodialysis patients. Especially the patients with isolated anti-HBc positivity should be tested for probable occult hepatitis B infection.
Açıklama
1st John H Dirks Chronic Renal Disease Prevention on Prevention Strategies for Chronic Kidney Disease in Latin America -- NOV 21-23, 2005 -- Vallarica, CHILE
karakan, tarkan/0000-0003-1561-8789; Mert, Ali/0000-0001-8945-2385
karakan, tarkan/0000-0003-1561-8789; Mert, Ali/0000-0001-8945-2385
Anahtar Kelimeler
hemodialysis, occult hepatitis, chronic renal failure
Kaynak
Renal Failure
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
28
Sayı
8
Künye
closedAccess
